Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety
Pritam Thapa
1
,
Radha Karki
1
,
Minho Yun
1
,
Tara Man Kadayat
1
,
Yong-Ho Lee
2
,
Han Jo Kwon
2
,
YOUNGHWA NA
3
,
W S Cho
4
,
N G Kim
5
,
Byeong-Ho Jeong
1
,
Youngjoo Kwon
2
,
Eung Ho Lee
1
1
5
New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 706-010, Republic of Korea
|
Publication type: Journal Article
Publication date: 2012-06-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
22503656
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
We have designed and synthesized a series of 2,4,6-triaryl pyridine derivatives containing chlorophenyl and phenolic moeity at 2- and 4- position of the central pyridine, respectively, resulting in a total of 42 compounds. They were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Most compounds showed better topoisomerase II inhibitory activity compared to topoisomerase I inhibitory activity. Compounds 19, 20, 26-28, and 47-50 especially showed stronger topo II inhibitory activity than etoposide.
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64
Total citations:
64
Citations from 2025:
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(6.25%)
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GOST
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Thapa P. et al. Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety // European Journal of Medicinal Chemistry. 2012. Vol. 52. pp. 123-136.
GOST all authors (up to 50)
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Thapa P., Karki R., Yun M., Kadayat T. M., Lee Y., Kwon H. J., NA Y., Cho W. S., Kim N. G., Jeong B., Kwon Y., Lee E. H. Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety // European Journal of Medicinal Chemistry. 2012. Vol. 52. pp. 123-136.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.ejmech.2012.03.010
UR - https://doi.org/10.1016/j.ejmech.2012.03.010
TI - Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety
T2 - European Journal of Medicinal Chemistry
AU - Thapa, Pritam
AU - Karki, Radha
AU - Yun, Minho
AU - Kadayat, Tara Man
AU - Lee, Yong-Ho
AU - Kwon, Han Jo
AU - NA, YOUNGHWA
AU - Cho, W S
AU - Kim, N G
AU - Jeong, Byeong-Ho
AU - Kwon, Youngjoo
AU - Lee, Eung Ho
PY - 2012
DA - 2012/06/01
PB - Elsevier
SP - 123-136
VL - 52
PMID - 22503656
SN - 0223-5234
SN - 1768-3254
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2012_Thapa,
author = {Pritam Thapa and Radha Karki and Minho Yun and Tara Man Kadayat and Yong-Ho Lee and Han Jo Kwon and YOUNGHWA NA and W S Cho and N G Kim and Byeong-Ho Jeong and Youngjoo Kwon and Eung Ho Lee},
title = {Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety},
journal = {European Journal of Medicinal Chemistry},
year = {2012},
volume = {52},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/j.ejmech.2012.03.010},
pages = {123--136},
doi = {10.1016/j.ejmech.2012.03.010}
}