In vitro cytotoxicity studies of palladacyclic complexes containing the symmetric diphosphine bridging ligand. Studies of their interactions with DNA and BSA
Kazem Karami
1
,
Mahboubeh Hosseini-Kharat
1
,
Hojjat Sadeghi-Aliabadi
2
,
J. Lipkowski
3
,
Mina Mirian
4
Publication type: Journal Article
Publication date: 2014-02-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
24374348
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
The reactions between [Pd2{(C,N)-C6H4CH2NH(Et)}2(μ-X)2] (X = Cl or Br) and 1,2-bis(diphenylphosphino)ethane (dppe) in the 1:1 molar ratio resulted in the dppe-bridged Pd(II) complexes, [Pd2{(C,N)-C6H4CH2NH(Et)}2(μ-dppe)(Cl)2] (1) and [Pd2{(C,N)-C6H4CH2NH(Et)}2(μ-dppe)(Br)2] (2), respectively, which were characterized by elemental analyses, infrared (IR), (1)H- and (31)P{(1)H} NMR spectroscopy. The molecular structure of 1 was determined by single-crystal X-ray diffraction. In vitro cytotoxicity of 1, 2, dppe, PhCH2NH(Et) and cisplatin were carried out against four human tumor cell lines. The interactions of complexes towards DNA and protein are investigated. The results suggested that both complexes could interact with FS-DNA through the intercalation mode. Moreover, the reactivity towards BSA revealed that the microenvironment and the secondary structure of BSA were changed in the presence of Pd(II) complexes.
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Karami K. et al. In vitro cytotoxicity studies of palladacyclic complexes containing the symmetric diphosphine bridging ligand. Studies of their interactions with DNA and BSA // European Journal of Medicinal Chemistry. 2014. Vol. 73. pp. 8-17.
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Karami K., Hosseini-Kharat M., Sadeghi-Aliabadi H., Lipkowski J., Mirian M. In vitro cytotoxicity studies of palladacyclic complexes containing the symmetric diphosphine bridging ligand. Studies of their interactions with DNA and BSA // European Journal of Medicinal Chemistry. 2014. Vol. 73. pp. 8-17.
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TY - JOUR
DO - 10.1016/j.ejmech.2013.11.042
UR - https://doi.org/10.1016/j.ejmech.2013.11.042
TI - In vitro cytotoxicity studies of palladacyclic complexes containing the symmetric diphosphine bridging ligand. Studies of their interactions with DNA and BSA
T2 - European Journal of Medicinal Chemistry
AU - Karami, Kazem
AU - Hosseini-Kharat, Mahboubeh
AU - Sadeghi-Aliabadi, Hojjat
AU - Lipkowski, J.
AU - Mirian, Mina
PY - 2014
DA - 2014/02/01
PB - Elsevier
SP - 8-17
VL - 73
PMID - 24374348
SN - 0223-5234
SN - 1768-3254
ER -
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@article{2014_Karami,
author = {Kazem Karami and Mahboubeh Hosseini-Kharat and Hojjat Sadeghi-Aliabadi and J. Lipkowski and Mina Mirian},
title = {In vitro cytotoxicity studies of palladacyclic complexes containing the symmetric diphosphine bridging ligand. Studies of their interactions with DNA and BSA},
journal = {European Journal of Medicinal Chemistry},
year = {2014},
volume = {73},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.ejmech.2013.11.042},
pages = {8--17},
doi = {10.1016/j.ejmech.2013.11.042}
}