A review on anticancer potential of bioactive heterocycle quinoline
Obaid Afzal
1
,
Suresh Kumar
1
,
Md Rafi Haider
1
,
Md Rahmat Ali
1
,
Rajiv Kumar
1
,
Manu Jaggi
2
,
Sandhya Bawa
1
1
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India
|
2
Dabur Research Foundation, Ghaziabad, Uttar Pradesh, India.
|
Publication type: Journal Article
Publication date: 2015-06-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
25073919
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
The advent of Camptothecin added a new dimension in the field anticancer drug development containing quinoline motif. Quinoline scaffold plays an important role in anticancer drug development as their derivatives have shown excellent results through different mechanism of action such as growth inhibitors by cell cycle arrest, apoptosis, inhibition of angiogenesis, disruption of cell migration, and modulation of nuclear receptor responsiveness. The anti-cancer potential of several of these derivatives have been demonstrated on various cancer cell lines. In this review we have compiled and discussed specifically the anticancer potential of quinoline derivatives, which could provide a low-height flying bird's eye view of the quinoline derived compounds to a medicinal chemist for a comprehensive and target oriented information for development of clinically viable anticancer drugs.
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Afzal O. et al. A review on anticancer potential of bioactive heterocycle quinoline // European Journal of Medicinal Chemistry. 2015. Vol. 97. pp. 871-910.
GOST all authors (up to 50)
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Afzal O., Kumar S., Haider M. R., Ali M. R., Kumar R., Jaggi M., Bawa S. A review on anticancer potential of bioactive heterocycle quinoline // European Journal of Medicinal Chemistry. 2015. Vol. 97. pp. 871-910.
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TY - JOUR
DO - 10.1016/j.ejmech.2014.07.044
UR - https://doi.org/10.1016/j.ejmech.2014.07.044
TI - A review on anticancer potential of bioactive heterocycle quinoline
T2 - European Journal of Medicinal Chemistry
AU - Afzal, Obaid
AU - Kumar, Suresh
AU - Haider, Md Rafi
AU - Ali, Md Rahmat
AU - Kumar, Rajiv
AU - Jaggi, Manu
AU - Bawa, Sandhya
PY - 2015
DA - 2015/06/01
PB - Elsevier
SP - 871-910
VL - 97
PMID - 25073919
SN - 0223-5234
SN - 1768-3254
ER -
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BibTex (up to 50 authors)
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@article{2015_Afzal,
author = {Obaid Afzal and Suresh Kumar and Md Rafi Haider and Md Rahmat Ali and Rajiv Kumar and Manu Jaggi and Sandhya Bawa},
title = {A review on anticancer potential of bioactive heterocycle quinoline},
journal = {European Journal of Medicinal Chemistry},
year = {2015},
volume = {97},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/j.ejmech.2014.07.044},
pages = {871--910},
doi = {10.1016/j.ejmech.2014.07.044}
}