Cyclopalladated primary amines: A preliminary study of antiproliferative activity through apoptosis induction
Joan Albert
1
,
Ramón Bosque
1
,
Manuel Garcia Martinez
1
,
Graciela García
2
,
Jaume Granell
1
,
Concepción López
2
,
María Victoria Lovelle
2
,
Romana Qadir
2
,
Asensio González
3, 4
,
Anusha Jayaraman
3, 5
,
Enric Mila
3
,
Roldán Cortés
3
,
Josefina Quirante
6
,
Carme Calvis
7
,
Ramon Messeguer
7
,
J. Badia
3, 8
,
L. Baldoma
3
4
6
7
Biomed Division LEITAT Technological Center, Parc Científic, Edifici Hèlix, C/ Baldiri Reixach, 15-21, 08028 Barcelona, Spain.
|
Publication type: Journal Article
Publication date: 2014-09-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
25063943
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
Twelve cyclometallated palladium(II) complexes containing primary aromatic amines [benzylamine (a), (R)-1-(1-naphthyl)ethylamine (b) and 2-phenylaniline (c)] as anionic bidentate (C,N)(-) ligands have been evaluated against a panel of human adenocarcinoma cell lines (A549 lung, MDA-MB231 and MCF7 breast, and the cisplatin resistant HCT116 colon). The results revealed a remarkable antiproliferative activity of the triphenylphosphane mononuclear compounds 3-4 (series a, b, c) and the best inhibition was provided for 3c and 4c with the 2-phenylaniline ligand and a six membered chelate ring. Interestingly, 3c and 4c were 14 and 19 times more potent than cisplatin for the inhibition of the cisplatin resistant HCT116 human adenocarcinoma cell line, respectively. Cyclopalladated complexes 3c and 4c exercise their antiproliferative activity over A549 cells mainly through the induction of apoptosis (38 and 31-fold increase in early apoptotic cells, respectively).
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Albert J. et al. Cyclopalladated primary amines: A preliminary study of antiproliferative activity through apoptosis induction // European Journal of Medicinal Chemistry. 2014. Vol. 84. pp. 530-536.
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Albert J., Bosque R., Martinez M. G., García G., Granell J., López C., Lovelle M. V., Qadir R., González A., Jayaraman A., Mila E., Cortés R., Quirante J., Calvis C., Messeguer R., Badia J., Baldoma L. Cyclopalladated primary amines: A preliminary study of antiproliferative activity through apoptosis induction // European Journal of Medicinal Chemistry. 2014. Vol. 84. pp. 530-536.
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TY - JOUR
DO - 10.1016/j.ejmech.2014.07.046
UR - https://doi.org/10.1016/j.ejmech.2014.07.046
TI - Cyclopalladated primary amines: A preliminary study of antiproliferative activity through apoptosis induction
T2 - European Journal of Medicinal Chemistry
AU - Albert, Joan
AU - Bosque, Ramón
AU - Martinez, Manuel Garcia
AU - García, Graciela
AU - Granell, Jaume
AU - López, Concepción
AU - Lovelle, María Victoria
AU - Qadir, Romana
AU - González, Asensio
AU - Jayaraman, Anusha
AU - Mila, Enric
AU - Cortés, Roldán
AU - Quirante, Josefina
AU - Calvis, Carme
AU - Messeguer, Ramon
AU - Badia, J.
AU - Baldoma, L.
PY - 2014
DA - 2014/09/01
PB - Elsevier
SP - 530-536
VL - 84
PMID - 25063943
SN - 0223-5234
SN - 1768-3254
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2014_Albert,
author = {Joan Albert and Ramón Bosque and Manuel Garcia Martinez and Graciela García and Jaume Granell and Concepción López and María Victoria Lovelle and Romana Qadir and Asensio González and Anusha Jayaraman and Enric Mila and Roldán Cortés and Josefina Quirante and Carme Calvis and Ramon Messeguer and J. Badia and L. Baldoma},
title = {Cyclopalladated primary amines: A preliminary study of antiproliferative activity through apoptosis induction},
journal = {European Journal of Medicinal Chemistry},
year = {2014},
volume = {84},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/j.ejmech.2014.07.046},
pages = {530--536},
doi = {10.1016/j.ejmech.2014.07.046}
}