Benzotriazole: An overview on its versatile biological behavior
Publication type: Journal Article
Publication date: 2015-06-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
25293580
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
Discovered in late 1960, azoles are heterocyclic compounds class which constitute the largest group of available antifungal drugs. Particularly, the imidazole ring is the chemical component that confers activity to azoles. Triazoles are obtained by a slight modification of this ring and similar or improved activities as well as less adverse effects are reported for triazole derivatives. Consequently, it is not surprising that benzimidazole/benzotriazole derivatives have been found to be biologically active. Since benzimidazole has been widely investigated, this review is focused on defining the place of benzotriazole derivatives in biomedical research, highlighting their versatile biological properties, the mode of action and Structure Activity Relationship (SAR) studies for a variety of antimicrobial, antiparasitic, and even antitumor, choleretic, cholesterol-lowering agents.
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190
Total citations:
190
Citations from 2025:
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(16.32%)
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GOST
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Briguglio I. et al. Benzotriazole: An overview on its versatile biological behavior // European Journal of Medicinal Chemistry. 2015. Vol. 97. pp. 612-648.
GOST all authors (up to 50)
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Briguglio I., Piras S., Corona P., Gavini E., Nieddu M., Boatto G., Carta A. Benzotriazole: An overview on its versatile biological behavior // European Journal of Medicinal Chemistry. 2015. Vol. 97. pp. 612-648.
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TY - JOUR
DO - 10.1016/j.ejmech.2014.09.089
UR - https://doi.org/10.1016/j.ejmech.2014.09.089
TI - Benzotriazole: An overview on its versatile biological behavior
T2 - European Journal of Medicinal Chemistry
AU - Briguglio, Irene
AU - Piras, Sandra
AU - Corona, Paola
AU - Gavini, Elisabetta
AU - Nieddu, M.
AU - Boatto, G
AU - Carta, Antonio
PY - 2015
DA - 2015/06/01
PB - Elsevier
SP - 612-648
VL - 97
PMID - 25293580
SN - 0223-5234
SN - 1768-3254
ER -
Cite this
BibTex (up to 50 authors)
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@article{2015_Briguglio,
author = {Irene Briguglio and Sandra Piras and Paola Corona and Elisabetta Gavini and M. Nieddu and G Boatto and Antonio Carta},
title = {Benzotriazole: An overview on its versatile biological behavior},
journal = {European Journal of Medicinal Chemistry},
year = {2015},
volume = {97},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/j.ejmech.2014.09.089},
pages = {612--648},
doi = {10.1016/j.ejmech.2014.09.089}
}