Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline–thiazolidine-based hybrids
1
Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska Street, Lviv, 79010, Ukraine.
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Publication type: Journal Article
Publication date: 2016-05-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
26922234
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
The features of the chemistry of 4-thiazolidinone and pyrazole/pyrazolines as pharmacologically attractive scaffolds were described in a number of reviews in which the main approaches to the synthesis of mentioned heterocycles and their biological activity were analyzed. However, the pyrazole/pyrazoline-thiazolidine-based hybrids as biologically active compounds is poorly discussed in the context of pharmacophore hybrid approach. Therefore, the purpose of this review is to summarize the data about the synthesis and modification of heterocyclic systems with thiazolidine and pyrazoline or pyrazole fragments in molecules as promising objects of modern bioorganic and medicinal chemistry. The description of biological activity was focused on SAR analysis and mechanistic insights of mentioned hybrids.
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148
Total citations:
148
Citations from 2025:
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(12.84%)
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Roman O., Lesyk R. Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline–thiazolidine-based hybrids // European Journal of Medicinal Chemistry. 2016. Vol. 113. pp. 145-166.
GOST all authors (up to 50)
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Roman O., Lesyk R. Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline–thiazolidine-based hybrids // European Journal of Medicinal Chemistry. 2016. Vol. 113. pp. 145-166.
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TY - JOUR
DO - 10.1016/j.ejmech.2016.02.030
UR - https://doi.org/10.1016/j.ejmech.2016.02.030
TI - Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline–thiazolidine-based hybrids
T2 - European Journal of Medicinal Chemistry
AU - Roman, Olexandra
AU - Lesyk, Roman
PY - 2016
DA - 2016/05/01
PB - Elsevier
SP - 145-166
VL - 113
PMID - 26922234
SN - 0223-5234
SN - 1768-3254
ER -
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BibTex (up to 50 authors)
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@article{2016_Havrylyuk,
author = {Olexandra Roman and Roman Lesyk},
title = {Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline–thiazolidine-based hybrids},
journal = {European Journal of Medicinal Chemistry},
year = {2016},
volume = {113},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/j.ejmech.2016.02.030},
pages = {145--166},
doi = {10.1016/j.ejmech.2016.02.030}
}