Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists
Yu Xue
1
,
Jingshu Tang
2
,
Xiaozhuo Ma
1
,
Qing Li
1
,
Bingxue Xie
1
,
Yuchen Hao
2
,
Hongwei Jin
1
,
Kewei Wang
2
,
Guisen Zhang
3
,
Liangren Zhang
1
,
Lihe Zhang
1
3
Jiangsu Nhwa Pharmaceutical Co. Ltd. 69 Minzhu South Road, Xuzhou, Jiangsu, 221116, PR China.
|
Publication type: Journal Article
Publication date: 2016-06-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
26994846
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
Human α7 nicotinic acetylcholine receptor (nAChR) is a promising therapeutic target for the treatment of schizophrenia accompanied with cognitive impairment. Herein, we report the synthesis and agonistic activities of a series of indolizine derivatives targeting to α7 nAChR. The results show that all synthesized compounds have affinity to α7 nAChR and some give strong agonistic activity, particularly most active agonists show higher potency than control EVP-6124. The docking and structure-activity relationship studies provide insights to develop more potent novel α7 nAChR agonists.
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Total citations:
37
Citations from 2025:
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(8.11%)
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RIS |
BibTex
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GOST
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Xue Yu. et al. Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists // European Journal of Medicinal Chemistry. 2016. Vol. 115. pp. 94-108.
GOST all authors (up to 50)
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Xue Yu., Tang J., Ma X., Li Q., Xie B., Hao Y., Jin H., Wang K., Zhang G., Zhang L., Zhang L. Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists // European Journal of Medicinal Chemistry. 2016. Vol. 115. pp. 94-108.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.ejmech.2016.03.016
UR - https://doi.org/10.1016/j.ejmech.2016.03.016
TI - Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists
T2 - European Journal of Medicinal Chemistry
AU - Xue, Yu
AU - Tang, Jingshu
AU - Ma, Xiaozhuo
AU - Li, Qing
AU - Xie, Bingxue
AU - Hao, Yuchen
AU - Jin, Hongwei
AU - Wang, Kewei
AU - Zhang, Guisen
AU - Zhang, Liangren
AU - Zhang, Lihe
PY - 2016
DA - 2016/06/01
PB - Elsevier
SP - 94-108
VL - 115
PMID - 26994846
SN - 0223-5234
SN - 1768-3254
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Xue,
author = {Yu Xue and Jingshu Tang and Xiaozhuo Ma and Qing Li and Bingxue Xie and Yuchen Hao and Hongwei Jin and Kewei Wang and Guisen Zhang and Liangren Zhang and Lihe Zhang},
title = {Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists},
journal = {European Journal of Medicinal Chemistry},
year = {2016},
volume = {115},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/j.ejmech.2016.03.016},
pages = {94--108},
doi = {10.1016/j.ejmech.2016.03.016}
}