Design, synthesis and antifungal activity of novel furancarboxamide derivatives
1
Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry
3
Chengdu 610064 China
|
Тип публикации: Journal Article
Дата публикации: 2016-09-01
scimago Q1
wos Q1
БС1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
27191618
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Краткое описание
Twenty-seven novel furancarboxamide derivatives with a diphenyl ether moiety were synthesized and evaluated for their antifungal activity against Rhizoctonia solani, Botrytis cirerea, Valsa mali and Sphaceloma ampelimum. Antifungal bioassay results indicated that most compounds had good or excellent fungicidal activities for R. solani and S. ampelimum at 20 mg L(-1). Among synthesized compounds, compound 18e showed a greater inhibitory effect against S. ampelimum, with half maximal effective concentration (EC50) values of 0.020 mg L(-1). This strong activity rivals currently used commercial fungicides, such as Boscalid and Carbendazim, and has great potential as a lead compound for future development of novel fungicides.
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ГОСТ
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Wen F. et al. Design, synthesis and antifungal activity of novel furancarboxamide derivatives // European Journal of Medicinal Chemistry. 2016. Vol. 120. pp. 244-251.
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Wen F., Jin H., Tao K., Hou T. Design, synthesis and antifungal activity of novel furancarboxamide derivatives // European Journal of Medicinal Chemistry. 2016. Vol. 120. pp. 244-251.
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TY - JOUR
DO - 10.1016/j.ejmech.2016.04.060
UR - https://linkinghub.elsevier.com/retrieve/pii/S0223523416303531
TI - Design, synthesis and antifungal activity of novel furancarboxamide derivatives
T2 - European Journal of Medicinal Chemistry
AU - Wen, Fang
AU - Jin, Hong
AU - Tao, Ke
AU - Hou, Taiping
PY - 2016
DA - 2016/09/01
PB - Elsevier
SP - 244-251
VL - 120
PMID - 27191618
SN - 0223-5234
SN - 1768-3254
ER -
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BibTex (до 50 авторов)
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@article{2016_Wen,
author = {Fang Wen and Hong Jin and Ke Tao and Taiping Hou},
title = {Design, synthesis and antifungal activity of novel furancarboxamide derivatives},
journal = {European Journal of Medicinal Chemistry},
year = {2016},
volume = {120},
publisher = {Elsevier},
month = {sep},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0223523416303531},
pages = {244--251},
doi = {10.1016/j.ejmech.2016.04.060}
}