European Journal of Medicinal Chemistry

, volume 138 , pages 293-299

Perylenyltriazoles inhibit reproduction of enveloped viruses.

Mikhail Baranov ¹

Gleb V Proskurin ¹

Liubov I. Kozlovskaya ^{2, 3}

Alexey A. Chistov ¹

Sergey V Kutyakov ¹

Galina G. Karganova ⁴

V. A. Palyulin ⁵

Dmitry I. Osolodkin ^{4, 5}

Vladimir A. Korshun ¹

Hide authors affiliations Show authors affiliations: 5 affiliations

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia. |

Chumakov Institute of Poliomyelitis and Viral Encephalitides, Chumakov FSC R&D IBP RAS, 108819 Moscow, Russia |

Sechenov First Moscow State Medical University, Moscow 119991, Russia. |

⁴

Sechenov First Moscow State Medical University, Moscow 119991, Russia |

⁵

Department of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia |

Publication type: Journal Article

Publication date: 2017-09-01

Elsevier

European Journal of Medicinal Chemistry

scimago Q1

wos Q1

SJR: 1.142

CiteScore: 11.3

Impact factor: 5.9

ISSN: 02235234, 17683254

DOI: 10.1016/j.ejmech.2017.06.014

Copy DOI

PubMed ID: 28675837

Organic Chemistry

Drug Discovery

General Medicine

Pharmacology

Abstract

1-Substituted 4-perylen-2(3)-yl-1,2,3-triazoles, easily accessible by 'click' reaction and combining in one molecule a polyaromatic unit and a nitrogen heterocycle, were found to strongly inhibit the reproduction of enveloped viruses. 5-[4-(Perylen-3-yl)-1,2,3-triazol-1-yl]-uridine and 2-[1-(2-hydroxyethyl)-1,2,3-triazol-4-yl]perylene show EC50 of 0.031 and 0.023 μM, respectively, against tick-borne encephalitis virus (TBEV). Remarkably, the nucleoside unit appears to be not essential for antiviral activity. These results provide deeper understanding of structural basis of activity for this new class of antivirals.

Found

13 citations

Osolodkin Dmitry

🥼 🤝

PhD in Chemistry

80 publications, 1 732 citations

h-index: 23

Sechenov First Moscow State Medical University

M.P. Chumakov Federal Scientific Center for Research and Development of Immunobiological Drugs of the Russian Academy of Sciences

2 citations

Belyaev Evgeny

🤝

PhD in Chemistry

35 publications, 224 citations

h-index: 10

A.N. Frumkin Institute of Physical Chemistry and Electrochemistry of the Russian Academy of Sciences

2 citations

Shtro Anna

🥼 🤝

PhD in Biological/biomedical sciences

73 publications, 1 172 citations, 1 review

h-index: 20

Smorodintsev Research Institute of Influenza

Research interests

Pharmacology

Virology

1 citation

Dotsenko Viktor

DSc in Chemistry, professor

249 publications, 2 805 citations, 2 reviews

h-index: 22

North Caucasus Federal University

Kuban State University

Research interests

Active methylene compounds

Biological activity

Heterocyclic compounds

Malononitrile

Selenoamides

Thioamides

1 citation

Vasilenko Dmitry

🥼 🤝

PhD in Chemistry

34 publications, 293 citations

h-index: 10

Lomonosov Moscow State University

Research interests

Medicinal Chemistry

Organic Chemistry

1 citation

Pestov Nikolay

PhD in Chemistry

69 publications, 1 080 citations, 4 reviews

h-index: 16

V. N. Orekhovich Research Institute of Biomedical Chemistry

M.P. Chumakov Federal Scientific Center for Research and Development of Immunobiological Drugs of the Russian Academy of Sciences

Research interests

Protein Engineering

1 citation

Galochkina Aнастасия

🤝

PhD in Biological/biomedical sciences

34 publications, 412 citations

h-index: 14

Smorodintsev Research Institute of Influenza

Top-30

Journals

	1 2 3 4
Annual Reports in Medicinal Chemistry	Annual Reports in Medicinal Chemistry, 4, 15.38% Annual Reports in Medicinal Chemistry 4 publications, 15.38%
Antiviral Research	Antiviral Research, 3, 11.54% Antiviral Research 3 publications, 11.54%
European Journal of Medicinal Chemistry	European Journal of Medicinal Chemistry, 3, 11.54% European Journal of Medicinal Chemistry 3 publications, 11.54%
Archiv der Pharmazie	Archiv der Pharmazie, 2, 7.69% Archiv der Pharmazie 2 publications, 7.69%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 2, 7.69% International Journal of Molecular Sciences 2 publications, 7.69%
ChemistrySelect	ChemistrySelect, 1, 3.85% ChemistrySelect 1 publication, 3.85%
Bioorganic Chemistry	Bioorganic Chemistry, 1, 3.85% Bioorganic Chemistry 1 publication, 3.85%
Molecules	Molecules, 1, 3.85% Molecules 1 publication, 3.85%
Pharmaceuticals	Pharmaceuticals, 1, 3.85% Pharmaceuticals 1 publication, 3.85%
Biomolecules	Biomolecules, 1, 3.85% Biomolecules 1 publication, 3.85%
Scientific Reports	Scientific Reports, 1, 3.85% Scientific Reports 1 publication, 3.85%
Bioorganic and Medicinal Chemistry Letters	Bioorganic and Medicinal Chemistry Letters, 1, 3.85% Bioorganic and Medicinal Chemistry Letters 1 publication, 3.85%
Molecular Informatics	Molecular Informatics, 1, 3.85% Molecular Informatics 1 publication, 3.85%
RSC Advances	RSC Advances, 1, 3.85% RSC Advances 1 publication, 3.85%
Current Issues in Molecular Biology	Current Issues in Molecular Biology, 1, 3.85% Current Issues in Molecular Biology 1 publication, 3.85%
ACS applied materials & interfaces	ACS applied materials & interfaces, 1, 3.85% ACS applied materials & interfaces 1 publication, 3.85%
Journal of Chemical Physics	Journal of Chemical Physics, 1, 3.85% Journal of Chemical Physics 1 publication, 3.85%
	1 2 3 4

Publishers

	2 4 6 8 10 12
Elsevier	Elsevier, 12, 46.15% Elsevier 12 publications, 46.15%
MDPI	MDPI, 6, 23.08% MDPI 6 publications, 23.08%
Wiley	Wiley, 4, 15.38% Wiley 4 publications, 15.38%
Springer Nature	Springer Nature, 1, 3.85% Springer Nature 1 publication, 3.85%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 3.85% Royal Society of Chemistry (RSC) 1 publication, 3.85%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 3.85% American Chemical Society (ACS) 1 publication, 3.85%
AIP Publishing	AIP Publishing, 1, 3.85% AIP Publishing 1 publication, 3.85%
	2 4 6 8 10 12

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST |

Cite this

GOST Copy

Baranov M. et al. Perylenyltriazoles inhibit reproduction of enveloped viruses. // European Journal of Medicinal Chemistry. 2017. Vol. 138. pp. 293-299.

GOST all authors (up to 50) Copy

Baranov M., Proskurin G. V., Kozlovskaya L. I., Chistov A. A., Kutyakov S. V., Karganova G. G., Palyulin V. A., Osolodkin D. I., Korshun V. A. Perylenyltriazoles inhibit reproduction of enveloped viruses. // European Journal of Medicinal Chemistry. 2017. Vol. 138. pp. 293-299.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.ejmech.2017.06.014

UR - https://doi.org/10.1016/j.ejmech.2017.06.014

TI - Perylenyltriazoles inhibit reproduction of enveloped viruses.

T2 - European Journal of Medicinal Chemistry

AU - Baranov, Mikhail

AU - Proskurin, Gleb V

AU - Kozlovskaya, Liubov I.

AU - Chistov, Alexey A.

AU - Kutyakov, Sergey V

AU - Karganova, Galina G.

AU - Palyulin, V. A.

AU - Osolodkin, Dmitry I.

AU - Korshun, Vladimir A.

PY - 2017

DA - 2017/09/01

PB - Elsevier

SP - 293-299

VL - 138

PMID - 28675837

SN - 0223-5234

SN - 1768-3254

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2017_Baranov,

author = {Mikhail Baranov and Gleb V Proskurin and Liubov I. Kozlovskaya and Alexey A. Chistov and Sergey V Kutyakov and Galina G. Karganova and V. A. Palyulin and Dmitry I. Osolodkin and Vladimir A. Korshun},

title = {Perylenyltriazoles inhibit reproduction of enveloped viruses.},

journal = {European Journal of Medicinal Chemistry},

year = {2017},

volume = {138},

publisher = {Elsevier},

month = {sep},

url = {https://doi.org/10.1016/j.ejmech.2017.06.014},

pages = {293--299},

doi = {10.1016/j.ejmech.2017.06.014}

}

Publisher

Elsevier

Journal

European Journal of Medicinal Chemistry

scimago Q1

wos Q1

SJR

1.142

CiteScore

11.3

Impact factor

5.9

ISSN

02235234 (Print)

17683254 (Electronic)

Labs

Laboratory of Antiviral medicines

Profiles