Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships.
Publication type: Journal Article
Publication date: 2019-10-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
31352246
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
Alzheimer's disease (AD) is a well known neurodegenerative disorder alarming millions of people worldwide and the subsequent epidemiological statistics highlights the implication of the disease. AD is a multi-factorial disease, a variety of single-target directed drugs that have reached clinical trials have unsuccessful. Hence, various factors associated without set of AD have been considered in targeted drug discovery and development. Triazoles are five-membered heterocyclic scaffold due to their broad range of biological activities. The present review focuses on the recent developments in the area of medicinal chemistry to explore the diverse chemical structures of potential inhibitors of Alzheimer's disease and also look at its structure-activity relationships (SAR) studies of bioactive compounds for future discovery of suitable drug candidates. The prominence has been given on the major advancements in the medicinal brochure of this pharmacophore for the period during 2012-2019.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
2
4
6
8
10
12
|
|
|
Journal of Molecular Structure
11 publications, 9.02%
|
|
|
Molecules
8 publications, 6.56%
|
|
|
European Journal of Medicinal Chemistry
8 publications, 6.56%
|
|
|
Bioorganic Chemistry
7 publications, 5.74%
|
|
|
RSC Advances
5 publications, 4.1%
|
|
|
Molecular Diversity
4 publications, 3.28%
|
|
|
New Journal of Chemistry
4 publications, 3.28%
|
|
|
ChemistrySelect
3 publications, 2.46%
|
|
|
ACS Chemical Neuroscience
3 publications, 2.46%
|
|
|
Chemistry and Biodiversity
3 publications, 2.46%
|
|
|
Advances in Heterocyclic Chemistry
2 publications, 1.64%
|
|
|
International Journal of Molecular Sciences
2 publications, 1.64%
|
|
|
Medicinal Chemistry Research
2 publications, 1.64%
|
|
|
International Journal of Biological Macromolecules
2 publications, 1.64%
|
|
|
Journal of the Iranian Chemical Society
2 publications, 1.64%
|
|
|
Bioorganic and Medicinal Chemistry Letters
2 publications, 1.64%
|
|
|
Archiv der Pharmazie
2 publications, 1.64%
|
|
|
Russian Journal of Organic Chemistry
2 publications, 1.64%
|
|
|
Journal of Enzyme Inhibition and Medicinal Chemistry
2 publications, 1.64%
|
|
|
Scientific Reports
2 publications, 1.64%
|
|
|
Polycyclic Aromatic Compounds
2 publications, 1.64%
|
|
|
Journal of Biomolecular Structure and Dynamics
2 publications, 1.64%
|
|
|
Current Organic Chemistry
1 publication, 0.82%
|
|
|
Anti-Cancer Agents in Medicinal Chemistry
1 publication, 0.82%
|
|
|
Current Drug Targets
1 publication, 0.82%
|
|
|
Future Medicinal Chemistry
1 publication, 0.82%
|
|
|
Catalysts
1 publication, 0.82%
|
|
|
Frontiers in Chemistry
1 publication, 0.82%
|
|
|
Frontiers in Physiology
1 publication, 0.82%
|
|
|
2
4
6
8
10
12
|
Publishers
|
5
10
15
20
25
30
35
40
45
|
|
|
Elsevier
43 publications, 35.25%
|
|
|
MDPI
14 publications, 11.48%
|
|
|
Springer Nature
13 publications, 10.66%
|
|
|
Wiley
12 publications, 9.84%
|
|
|
Royal Society of Chemistry (RSC)
12 publications, 9.84%
|
|
|
Taylor & Francis
10 publications, 8.2%
|
|
|
Bentham Science Publishers Ltd.
6 publications, 4.92%
|
|
|
American Chemical Society (ACS)
5 publications, 4.1%
|
|
|
Pleiades Publishing
3 publications, 2.46%
|
|
|
Frontiers Media S.A.
2 publications, 1.64%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 0.82%
|
|
|
Hacettepe University Journal of the Faculty of Pharmacy
1 publication, 0.82%
|
|
|
5
10
15
20
25
30
35
40
45
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
122
Total citations:
122
Citations from 2025:
24
(19.67%)
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Xu M. et al. Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships. // European Journal of Medicinal Chemistry. 2019. Vol. 180. pp. 656-672.
GOST all authors (up to 50)
Copy
Xu M., Peng Y., Zhu L., Wang S., Ji J., Rakesh K. P. Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships. // European Journal of Medicinal Chemistry. 2019. Vol. 180. pp. 656-672.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.ejmech.2019.07.059
UR - https://doi.org/10.1016/j.ejmech.2019.07.059
TI - Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships.
T2 - European Journal of Medicinal Chemistry
AU - Xu, Man
AU - Peng, Yongzhi
AU - Zhu, Li
AU - Wang, Shulin
AU - Ji, Jiayou
AU - Rakesh, K P
PY - 2019
DA - 2019/10/01
PB - Elsevier
SP - 656-672
VL - 180
PMID - 31352246
SN - 0223-5234
SN - 1768-3254
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Xu,
author = {Man Xu and Yongzhi Peng and Li Zhu and Shulin Wang and Jiayou Ji and K P Rakesh},
title = {Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships.},
journal = {European Journal of Medicinal Chemistry},
year = {2019},
volume = {180},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.ejmech.2019.07.059},
pages = {656--672},
doi = {10.1016/j.ejmech.2019.07.059}
}