1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships.
Publication type: Journal Article
Publication date: 2019-12-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
31546197
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
Anticancer agents are critical for the cancer treatment, but side effects and the drug resistance associated with the currently used anticancer agents create an urgent need to explore novel drugs with low side effects and high efficacy. 1,2,3-Triazole is privileged building block in the discovery of new anticancer agents, and some of its derivatives have already been applied in clinics or under clinical trials for fighting against cancers. Hybrid molecules occupy an important position in cancer control, and hybridization of 1,2,3-triazole framework with other anticancer pharmacophores may provide valuable therapeutic intervention for the treatment of cancer, especially drug-resistant cancer. This review emphasizes the recent advances in 1,2,3-triazole-containing hybrids with anticancer potential, covering articles published between 2015 and 2019, and the structure-activity relationships, together with mechanisms of action are also discussed.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
5
10
15
20
25
30
35
|
|
|
Molecules
34 publications, 7.98%
|
|
|
Journal of Molecular Structure
34 publications, 7.98%
|
|
|
ChemistrySelect
20 publications, 4.69%
|
|
|
Bioorganic Chemistry
18 publications, 4.23%
|
|
|
European Journal of Medicinal Chemistry
16 publications, 3.76%
|
|
|
Russian Journal of Bioorganic Chemistry
14 publications, 3.29%
|
|
|
ACS Omega
11 publications, 2.58%
|
|
|
New Journal of Chemistry
9 publications, 2.11%
|
|
|
Current Topics in Medicinal Chemistry
8 publications, 1.88%
|
|
|
Bioorganic and Medicinal Chemistry Letters
8 publications, 1.88%
|
|
|
Archiv der Pharmazie
8 publications, 1.88%
|
|
|
Russian Journal of Organic Chemistry
8 publications, 1.88%
|
|
|
International Journal of Molecular Sciences
7 publications, 1.64%
|
|
|
Polycyclic Aromatic Compounds
7 publications, 1.64%
|
|
|
Molecular Diversity
6 publications, 1.41%
|
|
|
RSC Advances
6 publications, 1.41%
|
|
|
Chemistry and Biodiversity
6 publications, 1.41%
|
|
|
RSC Medicinal Chemistry
5 publications, 1.17%
|
|
|
Current Organic Chemistry
5 publications, 1.17%
|
|
|
Catalysts
5 publications, 1.17%
|
|
|
Frontiers in Chemistry
5 publications, 1.17%
|
|
|
Bioorganic and Medicinal Chemistry
5 publications, 1.17%
|
|
|
Synthetic Communications
5 publications, 1.17%
|
|
|
Russian Journal of General Chemistry
4 publications, 0.94%
|
|
|
MolBank
4 publications, 0.94%
|
|
|
Frontiers in Pharmacology
4 publications, 0.94%
|
|
|
Research on Chemical Intermediates
4 publications, 0.94%
|
|
|
Journal of Medicinal Chemistry
4 publications, 0.94%
|
|
|
Journal of Enzyme Inhibition and Medicinal Chemistry
4 publications, 0.94%
|
|
|
Journal of Organic Chemistry
3 publications, 0.7%
|
|
|
5
10
15
20
25
30
35
|
Publishers
|
20
40
60
80
100
120
|
|
|
Elsevier
106 publications, 24.88%
|
|
|
MDPI
62 publications, 14.55%
|
|
|
Wiley
58 publications, 13.62%
|
|
|
Springer Nature
34 publications, 7.98%
|
|
|
Taylor & Francis
31 publications, 7.28%
|
|
|
Pleiades Publishing
27 publications, 6.34%
|
|
|
Royal Society of Chemistry (RSC)
27 publications, 6.34%
|
|
|
American Chemical Society (ACS)
25 publications, 5.87%
|
|
|
Bentham Science Publishers Ltd.
25 publications, 5.87%
|
|
|
Frontiers Media S.A.
11 publications, 2.58%
|
|
|
King Saud University
3 publications, 0.7%
|
|
|
Shanghai Institute of Organic Chemistry
2 publications, 0.47%
|
|
|
International Union of Crystallography (IUCr)
1 publication, 0.23%
|
|
|
Pharmaceutical Society of Japan
1 publication, 0.23%
|
|
|
Walter de Gruyter
1 publication, 0.23%
|
|
|
Hrvatsko Farmaceutsko Drustvo/Croatian Pharmaceutical Society
1 publication, 0.23%
|
|
|
Trans Tech Publications
1 publication, 0.23%
|
|
|
Asian Journal of Chemistry
1 publication, 0.23%
|
|
|
The Japan Institute of Heterocyclic Chemistry
1 publication, 0.23%
|
|
|
Beilstein-Institut
1 publication, 0.23%
|
|
|
National Library of Serbia
1 publication, 0.23%
|
|
|
The Royal Society
1 publication, 0.23%
|
|
|
Lviv Polytechnic National University
1 publication, 0.23%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 0.23%
|
|
|
Georg Thieme Verlag KG
1 publication, 0.23%
|
|
|
Public Library of Science (PLoS)
1 publication, 0.23%
|
|
|
20
40
60
80
100
120
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
426
Total citations:
426
Citations from 2024:
137
(32.16%)
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Xu Z., Zhao S., Liu Y. 1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships. // European Journal of Medicinal Chemistry. 2019. Vol. 183. p. 111700.
GOST all authors (up to 50)
Copy
Xu Z., Zhao S., Liu Y. 1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships. // European Journal of Medicinal Chemistry. 2019. Vol. 183. p. 111700.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.ejmech.2019.111700
UR - https://doi.org/10.1016/j.ejmech.2019.111700
TI - 1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships.
T2 - European Journal of Medicinal Chemistry
AU - Xu, Zhi
AU - Zhao, Shi‐Jia
AU - Liu, Yi
PY - 2019
DA - 2019/12/01
PB - Elsevier
SP - 111700
VL - 183
PMID - 31546197
SN - 0223-5234
SN - 1768-3254
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Xu,
author = {Zhi Xu and Shi‐Jia Zhao and Yi Liu},
title = {1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships.},
journal = {European Journal of Medicinal Chemistry},
year = {2019},
volume = {183},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.ejmech.2019.111700},
pages = {111700},
doi = {10.1016/j.ejmech.2019.111700}
}