A closer look at N2,6-substituted 1,3,5-triazine-2,4-diamines: Advances in synthesis and biological activities
Publication type: Journal Article
Publication date: 2022-11-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
35981459
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
N2,6-Substituted 1,3,5-triazine-2,4-diamines (N2-substituted guanamines) attracted significant interest due to their potential in the development of bioactive molecules. With just two points of diversity, this scaffold is proved to be suitable for constructing compounds targeting various enzymes, receptors, transporters, and nucleic acids with an array of therapeutic applications, particularly in cancer, inflammation, and CNS disorders. This review discusses progress in the synthesis of N2,6-substituted 1,3,5-triazine-2,4-diamines and their biological activities ranging from the inhibition of cancer-related enzymes (e.g. DNA topoisomerase IIα, carbonic anhydrases, ubiquitin-conjugating enzyme 2B, lysophosphatidic acid acyltransferase β and various kinases) to the binding to CNS-relevant receptors (e.g. histamine H4, serotonin 5-HT6, adenosine A2a, and α7 nicotinic acetylcholine receptors).
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16
Total citations:
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Citations from 2024:
11
(68.75%)
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Shahari M. S. B., Dolzhenko A. V. A closer look at N2,6-substituted 1,3,5-triazine-2,4-diamines: Advances in synthesis and biological activities // European Journal of Medicinal Chemistry. 2022. Vol. 241. p. 114645.
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Shahari M. S. B., Dolzhenko A. V. A closer look at N2,6-substituted 1,3,5-triazine-2,4-diamines: Advances in synthesis and biological activities // European Journal of Medicinal Chemistry. 2022. Vol. 241. p. 114645.
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TY - JOUR
DO - 10.1016/j.ejmech.2022.114645
UR - https://doi.org/10.1016/j.ejmech.2022.114645
TI - A closer look at N2,6-substituted 1,3,5-triazine-2,4-diamines: Advances in synthesis and biological activities
T2 - European Journal of Medicinal Chemistry
AU - Shahari, Muhammad Syafiq Bin
AU - Dolzhenko, Anton V.
PY - 2022
DA - 2022/11/01
PB - Elsevier
SP - 114645
VL - 241
PMID - 35981459
SN - 0223-5234
SN - 1768-3254
ER -
Cite this
BibTex (up to 50 authors)
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@article{2022_Shahari,
author = {Muhammad Syafiq Bin Shahari and Anton V. Dolzhenko},
title = {A closer look at N2,6-substituted 1,3,5-triazine-2,4-diamines: Advances in synthesis and biological activities},
journal = {European Journal of Medicinal Chemistry},
year = {2022},
volume = {241},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.ejmech.2022.114645},
pages = {114645},
doi = {10.1016/j.ejmech.2022.114645}
}