European Journal of Pharmaceutics and Biopharmaceutics

, volume 87 , issue 1 , pages 132-141

Biodegradable human serum albumin nanoparticles as contrast agents for the detection of hepatocellular carcinoma by magnetic resonance imaging

Waralee Watcharin ¹

Christian Schmithals ²

Thomas Pleli ²

Verena Köberle ²

Hüdayi Korkusuz ³

Frank Huebner ⁴

Stefan Zeuzem ¹

Hans W Korf ⁵

Thomas. J. Vogl ⁴

Claudia Rittmeyer ⁶

Andreas Terfort ⁶

Albrecht Piiper ¹

S.E Gelperina ⁷

Jörg Kreuter ¹

Hide authors affiliations Show authors affiliations: 7 affiliations

Institute of Pharmaceutical Technology, Goethe-University, Frankfurt, Germany. |

Department of Medicine I, University Hospital Frankfurt, Germany |

Department of Nuclear Medicine, University Hospital Frankfurt, Germany |

⁴

Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Germany |

⁵

Department of Anatomy, University Hospital Frankfurt, Germany |

⁶

Institute of Inorganic and Analytical Chemistry, Goethe University, Frankfurt, Germany |

⁷

Nanosystem Ltd, Moscow, Russia |

Publication type: Journal Article

Publication date: 2014-05-01

Elsevier

European Journal of Pharmaceutics and Biopharmaceutics

scimago Q1

wos Q1

SJR: 0.905

CiteScore: 7.9

Impact factor: 4.3

ISSN: 09396411, 18733441

DOI: 10.1016/j.ejpb.2013.12.010

Copy DOI

PubMed ID: 24365328

General Medicine

Pharmaceutical Science

Biotechnology

Abstract

Tumor visualization by magnetic resonance imaging (MRI) and nanoparticle-based contrast agents may improve the imaging of solid tumors such as hepatocellular carcinoma (HCC). In particular, human serum albumin (HSA) nanoparticles appear to be a suitable carrier due to their safety and feasibility of functionalization. In the present study HSA nanoparticles were conjugated with gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) using carbodiimide chemistry. The nanoparticles had a uniform spherical shape and a diameter of 235±19nm. For better optical visualization in vitro and in vivo, the HSA-Gd nanoparticles were additionally labeled with rhodamine 123. As shown by confocal microscopy and flow cytometry analysis, the fluorescent nanoparticles were readily taken up by Huh-7 hepatocellular carcinoma cells. After 24h incubation in blood serum, less than 5% of the Gd(III) was released from the particles, which suggests that this nanoparticulate system may be stable in vivo and, therefore, may serve as potentially safe T1 MRI contrast agent for MRI of hepatocellular carcinoma.

Found

2 citations

Akhmadeev Bulat

🥼 🤝

PhD in Chemistry

32 publications, 277 citations, 2 reviews

h-index: 10

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Magnetic resonance imaging (MRI)

Nanoparticles

Sensors

1 citation

Zairov Rustem

🥼 🤝

PhD in Chemistry, associate professor

141 publications, 1 695 citations, 373 reviews

h-index: 24

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Kazan Federal University

Southwest Petroleum University

Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

1 citation

Saraf Shubhini

156 publications, 3 038 citations, 24 reviews

h-index: 29

Babasaheb Bhimrao Ambedkar University

1 citation

Razumov Ivan

51 publications, 360 citations

h-index: 12

Novosibirsk State University

Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences

1 citation

Dovzhenko Aleksey

23 publications, 201 citations

h-index: 10

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Kazan Federal University

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GOST |

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GOST Copy

Watcharin W. et al. Biodegradable human serum albumin nanoparticles as contrast agents for the detection of hepatocellular carcinoma by magnetic resonance imaging // European Journal of Pharmaceutics and Biopharmaceutics. 2014. Vol. 87. No. 1. pp. 132-141.

GOST all authors (up to 50) Copy

Watcharin W., Schmithals C., Pleli T., Köberle V., Korkusuz H., Huebner F., Zeuzem S., Korf H. W., Vogl T. J., Rittmeyer C., Terfort A., Piiper A., Gelperina S., Kreuter J. Biodegradable human serum albumin nanoparticles as contrast agents for the detection of hepatocellular carcinoma by magnetic resonance imaging // European Journal of Pharmaceutics and Biopharmaceutics. 2014. Vol. 87. No. 1. pp. 132-141.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.ejpb.2013.12.010

UR - https://doi.org/10.1016/j.ejpb.2013.12.010

TI - Biodegradable human serum albumin nanoparticles as contrast agents for the detection of hepatocellular carcinoma by magnetic resonance imaging

T2 - European Journal of Pharmaceutics and Biopharmaceutics

AU - Watcharin, Waralee

AU - Schmithals, Christian

AU - Pleli, Thomas

AU - Köberle, Verena

AU - Korkusuz, Hüdayi

AU - Huebner, Frank

AU - Zeuzem, Stefan

AU - Korf, Hans W

AU - Vogl, Thomas. J.

AU - Rittmeyer, Claudia

AU - Terfort, Andreas

AU - Piiper, Albrecht

AU - Gelperina, S.E

AU - Kreuter, Jörg

PY - 2014

DA - 2014/05/01

PB - Elsevier

SP - 132-141

IS - 1

VL - 87

PMID - 24365328

SN - 0939-6411

SN - 1873-3441

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2014_Watcharin,

author = {Waralee Watcharin and Christian Schmithals and Thomas Pleli and Verena Köberle and Hüdayi Korkusuz and Frank Huebner and Stefan Zeuzem and Hans W Korf and Thomas. J. Vogl and Claudia Rittmeyer and Andreas Terfort and Albrecht Piiper and S.E Gelperina and Jörg Kreuter},

title = {Biodegradable human serum albumin nanoparticles as contrast agents for the detection of hepatocellular carcinoma by magnetic resonance imaging},

journal = {European Journal of Pharmaceutics and Biopharmaceutics},

year = {2014},

volume = {87},

publisher = {Elsevier},

month = {may},

url = {https://doi.org/10.1016/j.ejpb.2013.12.010},

number = {1},

pages = {132--141},

doi = {10.1016/j.ejpb.2013.12.010}

}

MLA

Cite this

MLA Copy

Watcharin, Waralee, et al. “Biodegradable human serum albumin nanoparticles as contrast agents for the detection of hepatocellular carcinoma by magnetic resonance imaging.” European Journal of Pharmaceutics and Biopharmaceutics, vol. 87, no. 1, May. 2014, pp. 132-141. https://doi.org/10.1016/j.ejpb.2013.12.010.

Publisher

Elsevier

Journal

European Journal of Pharmaceutics and Biopharmaceutics

scimago Q1

wos Q1

SJR

0.905

CiteScore

7.9

Impact factor

4.3

ISSN

09396411 (Print)

18733441 (Electronic)