Environmental Research, volume 212, pages 113218

Associations of prepubertal urinary phthalate metabolite concentrations with pubertal onset among a longitudinal cohort of boys

Burns Jane ¹

Sergeyev Oleg ^{2, 3}

Lee Mary M ^{4, 5}

Williams Paige L ⁶

Mínguez-Alarcón Lidia ^{7, 8}

Plaku-Alakbarova Bora ^{8, 9}

Sokolov S. A. ¹⁰

Kovalev Sergey ¹⁰

Koch Holger ¹¹

Lebedev Albert T. ¹⁰

Hauser R ⁸

Korrick S A ^{7, 8}

Hide authors affiliations Show authors affiliations: 11 affiliations

Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 1, Boston, MA, 02115, USA. Electronic address: jburns@hsph.harvard.edu.

Chapaevsk Medical Association, Meditsinskaya Str., 3a, Chapaevsk, Samara Region, 446100, Russia |

Group of Epigenetic Epidemiology, Belozersky Research Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskye Gory, House 1, Building 40, Room 322, 119992, Moscow, Russia |

⁴

Department of Pediatrics, Sidney Kimmel Medical School, Jefferson University, Philadelphia, PA, USA |

⁵

Nemours Children's Health, 1600 Rockland Road, Wilmington, 19803, USA |

⁶

Department of Biostatistics, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 2, Room 443, Boston, MA, 02115, USA |

⁷

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 401 Park Drive, 3rd Floor West, Boston, MA, 02215, USA |

⁸

⁹

Epidemiology Division, Optuminsight Life Sciences, Boston, MA, USA |

¹⁰

Chemistry Department, Lomonosov Moscow State University, Moscow, 119991, Leninskie Gory 1/3, Russian Federation |

¹¹

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance – Institute of the Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany |

Publication type: Journal Article

Publication date: 2022-09-01

Elsevier

Journal: Environmental Research

Quartile SCImago

Quartile WOS

Impact factor: 8.3

ISSN: 00139351, 10960953

DOI: 10.1016/j.envres.2022.113218

Copy DOI

PubMed ID: 35390299

Biochemistry

General Environmental Science

Abstract

Although phthalate exposures have been associated with adverse effects on male reproductive health, few studies have explored longitudinal associations with male pubertal development. We examined the association of prepubertal urinary concentrations of phthalate metabolites with age at pubertal onset in a prospective cohort of Russian boys. At enrollment at ages 8–9 years, medical history, dietary, and demographic information was collected. At entry and annually, physical examinations and pubertal staging [Genitalia (G), Pubarche (P), and testicular volume (TV, in ml)] were conducted and spot urines were collected. Prepubertal urine samples (defined as either TV = 1, 2 and G = 1, 2 or TV = 3 and G = 1) were pooled for each boy and phthalate metabolite concentrations were quantified using isotope dilution LC-MS/MS at Moscow State University. We measured 15 metabolites including those from anti-androgenic parent phthalates (AAPs) such as di (2-ethylhexyl) (DEHP) and di-isononyl (DiNP) phthalates as well as monobenzyl (MBzP), mono-n-butyl (MnBP), and mono-isobutyl (MiBP) metabolites. We calculated the molar sums of DEHP (∑DEHP), DiNP (∑DiNP), and AAP (∑AAP) metabolites. Separate interval-censored models were used to assess associations of quartiles of prepubertal phthalate metabolites with each pubertal onset indicator, G2+, P2+ and TV > 3 mL, adjusted for covariates and urine specific gravity . 304 boys had 752 prepubertal urine samples (median 2, range: 1–6) for pooling. In adjusted models, higher urinary AAPs were consistently associated with later pubertal onset (P2) with mean shifts ranging from 8.4 to 14.2 months for the highest versus lowest quartiles. Significantly later onset for G2 and TV > 3 mL was observed for higher versus lower quartiles of MiBP, MBzP, ∑DEHP and ∑DiNP. On average, boys with higher concentrations of prepubertal urinary AAPs had later pubertal onset by six months to over a year. The impact of AAPs on timing of male puberty may be attributable to disruption of androgen-dependent biological pathways. • Russian boys' urinary phthalate metabolite levels were higher than in Europe and US. • Overall, mean age of pubertal onset in our cohort was similar to other populations. • Higher urinary anti-androgenic phthalates were associated with later male pubarche. • Higher anti-androgenic phthalates were associated with later male gonadarche.

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Citations by journals

	1
Analytical Methods	Analytical Methods, 1, 12.5% Analytical Methods 1 publication, 12.5%
Frontiers in Endocrinology	Frontiers in Endocrinology, 1, 12.5% Frontiers in Endocrinology 1 publication, 12.5%
Environmental International	Environmental International, 1, 12.5% Environmental International 1 publication, 12.5%
Ecotoxicology and Environmental Safety	Ecotoxicology and Environmental Safety, 1, 12.5% Ecotoxicology and Environmental Safety 1 publication, 12.5%
Science of the Total Environment	Science of the Total Environment, 1, 12.5% Science of the Total Environment 1 publication, 12.5%
Journal of Hazardous Materials	Journal of Hazardous Materials, 1, 12.5% Journal of Hazardous Materials 1 publication, 12.5%
Toxicological Sciences	Toxicological Sciences, 1, 12.5% Toxicological Sciences 1 publication, 12.5%
Fertility and Sterility	Fertility and Sterility, 1, 12.5% Fertility and Sterility 1 publication, 12.5%
	1

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	1 2 3 4 5
Elsevier	Elsevier, 5, 62.5% Elsevier 5 publications, 62.5%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 12.5% Royal Society of Chemistry (RSC) 1 publication, 12.5%
Frontiers Media S.A.	Frontiers Media S.A., 1, 12.5% Frontiers Media S.A. 1 publication, 12.5%
Oxford University Press	Oxford University Press, 1, 12.5% Oxford University Press 1 publication, 12.5%
	1 2 3 4 5

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Burns J. et al. Associations of prepubertal urinary phthalate metabolite concentrations with pubertal onset among a longitudinal cohort of boys // Environmental Research. 2022. Vol. 212. p. 113218.

GOST all authors (up to 50) Copy

Burns J., Sergeyev O., Lee M. M., Williams P. L., Mínguez-Alarcón L., Plaku-Alakbarova B., Sokolov S. A., Kovalev S., Koch H., Lebedev A. T., Hauser R., Korrick S. A. Associations of prepubertal urinary phthalate metabolite concentrations with pubertal onset among a longitudinal cohort of boys // Environmental Research. 2022. Vol. 212. p. 113218.

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RIS Copy

TY - JOUR

DO - 10.1016/j.envres.2022.113218

UR - https://doi.org/10.1016%2Fj.envres.2022.113218

TI - Associations of prepubertal urinary phthalate metabolite concentrations with pubertal onset among a longitudinal cohort of boys

T2 - Environmental Research

AU - Burns, Jane

AU - Sergeyev, Oleg

AU - Lee, Mary M

AU - Williams, Paige L

AU - Mínguez-Alarcón, Lidia

AU - Plaku-Alakbarova, Bora

AU - Sokolov, S. A.

AU - Kovalev, Sergey

AU - Koch, Holger

AU - Lebedev, Albert T.

AU - Hauser, R

AU - Korrick, S A

PY - 2022

DA - 2022/09/01 00:00:00

PB - Elsevier

SP - 113218

VL - 212

PMID - 35390299

SN - 0013-9351

SN - 1096-0953

ER -

BibTex

Cite this

BibTex Copy

@article{2022_Burns,

author = {Jane Burns and Oleg Sergeyev and Mary M Lee and Paige L Williams and Lidia Mínguez-Alarcón and Bora Plaku-Alakbarova and S. A. Sokolov and Sergey Kovalev and Holger Koch and Albert T. Lebedev and R Hauser and S A Korrick},

title = {Associations of prepubertal urinary phthalate metabolite concentrations with pubertal onset among a longitudinal cohort of boys},

journal = {Environmental Research},

year = {2022},

volume = {212},

publisher = {Elsevier},

month = {sep},

url = {https://doi.org/10.1016%2Fj.envres.2022.113218},

pages = {113218},

doi = {10.1016/j.envres.2022.113218}

}

Found error?

Publisher

Elsevier

Journal

Environmental Research

Quartile SCImago

Quartile WOS

Impact factor

8.3

ISSN

00139351 (Print)
10960953 (Electronic)

Labs

Laboratory of physico-chemical methods for the analysis of the structure of matter

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