POxylation as an alternative stealth coating for biomedical applications
Herdis Bludau
1
,
Anna E Czapar
2
,
Andrzej S Pitek
3
,
Sourabh Shukla
3
,
Rainer A. Jordan
1
,
Nicole F Steinmetz
4
1
Chair of Macromolecular Chemistry, School of Science, Technische Unversität Dresden, Mommsenstr. 4, 01069 Dresden, Germany
|
Publication type: Journal Article
Publication date: 2017-03-01
scimago Q1
wos Q1
SJR: 1.076
CiteScore: 10.2
Impact factor: 6.3
ISSN: 00143057, 18731945
PubMed ID:
28713172
Materials Chemistry
Organic Chemistry
General Physics and Astronomy
Polymers and Plastics
Abstract
Polyethylene glycol (PEG) polymers are currently used in a variety of medical formulations to reduce toxicity, minimize immune interactions and improve pharmacokinetics. Despite its widespread use however, the presence of anti-PEG antibodies indicates that this polymer has the potential to be immunogenic and antigenic. Here we present an alternative polymer, poly(2-oxazoline) (POx) for stealth applications, specifically shielding of a proteinaceous nanoparticle from recognition by the immune system. Tobacco mosaic virus (TMV) was used as our testbed due to its potential for use as a nanocarrier for drug delivery and molecular imaging applications.
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94
Total citations:
94
Citations from 2024:
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(18.08%)
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GOST
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Bludau H. et al. POxylation as an alternative stealth coating for biomedical applications // European Polymer Journal. 2017. Vol. 88. pp. 679-688.
GOST all authors (up to 50)
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Bludau H., Czapar A. E., Pitek A. S., Shukla S., Jordan R. A., Steinmetz N. F. POxylation as an alternative stealth coating for biomedical applications // European Polymer Journal. 2017. Vol. 88. pp. 679-688.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.eurpolymj.2016.10.041
UR - https://doi.org/10.1016/j.eurpolymj.2016.10.041
TI - POxylation as an alternative stealth coating for biomedical applications
T2 - European Polymer Journal
AU - Bludau, Herdis
AU - Czapar, Anna E
AU - Pitek, Andrzej S
AU - Shukla, Sourabh
AU - Jordan, Rainer A.
AU - Steinmetz, Nicole F
PY - 2017
DA - 2017/03/01
PB - Elsevier
SP - 679-688
VL - 88
PMID - 28713172
SN - 0014-3057
SN - 1873-1945
ER -
Cite this
BibTex (up to 50 authors)
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@article{2017_Bludau,
author = {Herdis Bludau and Anna E Czapar and Andrzej S Pitek and Sourabh Shukla and Rainer A. Jordan and Nicole F Steinmetz},
title = {POxylation as an alternative stealth coating for biomedical applications},
journal = {European Polymer Journal},
year = {2017},
volume = {88},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.eurpolymj.2016.10.041},
pages = {679--688},
doi = {10.1016/j.eurpolymj.2016.10.041}
}