Preparation of diblock amphiphilic polypeptide nanoparticles for medical applications
Publication type: Journal Article
Publication date: 2018-03-01
scimago Q1
wos Q1
SJR: 1.076
CiteScore: 10.2
Impact factor: 6.3
ISSN: 00143057, 18731945
Materials Chemistry
Organic Chemistry
General Physics and Astronomy
Polymers and Plastics
Abstract
We reported a series of diblock amphiphilic copolypeptides consisting of polylysine and phenylalanine that could self-assemble into different kinds of nanoparticles according to the length ratio of the hydrophobic and hydrophilic chains. Dynamic light scattering (DLS), transmission electron microscopy (TEM), and atomic force microscopy (AFM) confirmed the self-assembled structure of the diblock amphiphilic copolypeptides. The copolypeptides could self-assemble into rodlike micelles, vesicles, and wormlike vesicles due to different ratios of the hydrophobic and hydrophilic chains. The critical vesicle formation concentration (CVC), DOX loading and in vitro release were also studied. These antibacterial peptide nanoparticles are promising candidate for biomedical application, and they can inhibit bacterial infection simultaneously.
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Total citations:
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GOST
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Zhou X., Su X., Zhou C. Preparation of diblock amphiphilic polypeptide nanoparticles for medical applications // European Polymer Journal. 2018. Vol. 100. pp. 132-136.
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Zhou X., Su X., Zhou C. Preparation of diblock amphiphilic polypeptide nanoparticles for medical applications // European Polymer Journal. 2018. Vol. 100. pp. 132-136.
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TY - JOUR
DO - 10.1016/j.eurpolymj.2018.01.025
UR - https://doi.org/10.1016/j.eurpolymj.2018.01.025
TI - Preparation of diblock amphiphilic polypeptide nanoparticles for medical applications
T2 - European Polymer Journal
AU - Zhou, Xinyu
AU - Su, Xiaokai
AU - Zhou, Chuncai
PY - 2018
DA - 2018/03/01
PB - Elsevier
SP - 132-136
VL - 100
SN - 0014-3057
SN - 1873-1945
ER -
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@article{2018_Zhou,
author = {Xinyu Zhou and Xiaokai Su and Chuncai Zhou},
title = {Preparation of diblock amphiphilic polypeptide nanoparticles for medical applications},
journal = {European Polymer Journal},
year = {2018},
volume = {100},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.eurpolymj.2018.01.025},
pages = {132--136},
doi = {10.1016/j.eurpolymj.2018.01.025}
}