Polyoxazoline: A review article from polymerization to smart behaviors and biomedical applications

• Polyoxazolines are emerging innovative biomaterials that show analogous and even preferable properties compared to well-known counterparts. • This paper reviews different derivatives of polyoxazoline and their properties, which are applied in tissue engineering. • Summarized current challenges and different aspects can be study in near future. • Polyoxazolines can be synthesized in a living and hence controlled manner using the cationic ring-opening polymerization method. Different methods of synthesis of polyoxazolines are reviewed. • Smart behaviors of polyoxazoline make it a suitable material for tissue and biomedical engineering, especially for drug delivery approach. In this review paper, different smart behaviors of polyoxazolines derivatives are described. • Polyoxazoline is an appropriate selection for delivery systems due to its favorable performance and properties. In this review, applications of polyoxazolines in drug, protein, gene delivery systems are described. • Prepared two table pointing to various polyoxazoline delivery systems and different methods of preparing biomaterial scaffolds for application in tissue engineering. Poly(2-oxazoline) s are emerging innovative biomaterials that show analogous and even preferable properties compared to well-known counterparts, especially poly(ethylene glycol). This polymer can be synthesized in a living and hence controlled manner using the cationic ring-opening polymerization method. In addition, various polyoxazolines are water-soluble or amphiphilic and relatively non-toxic, making them attractive as biomaterials. Polyoxazolines (10 and 20 kDa) are safe when used intravenously to rats and can be used for several biomedical applications. These results from various papers and patents conclude that POx is a favorable biopolymer. The present review aims to highlight the synthesis, structure, and properties of polyoxazolines, such as different derivatives of POx used in tissue engineering. Different polymerization methods and smart behaviors of POx are described as well. Finally, it aims to introduce the significance and potential of POx in biomedical applications like drug delivery, protein delivery, and gene delivery using a number of leading references of recent years.