Elsevier
Experimental Parasitology
,  volume 266 ,  pages 108839

Effects of Cardanol-Based Phospholipid Analogs on Trichomonas vaginalis

Tatiana Guinancio De Souza 1
, 
Brenda de Lucena Costa 2
, 
Cleonice Andrade Holanda 2
, 
L. A. S. Romeiro 2
, 
Wanderley de Souza 1
, 
Marlene Benchimol 3
1
 
2
 
3
 
Publication type: Journal Article
Publication date: 2024-11-01
Elsevier
scimago Q3
wos Q3
SJR: 0.414
CiteScore: 2.8
Impact factor: 1.6
ISSN: 00144894, 10902449
Abstract
Trichomonas vaginalis is a protist parasite of the urogenital tract, responsible for human trichomoniasis, an infection sexually transmitted that affects approximately 156 million people worldwide. This pathology is more evident in females and can cause miscarriages, premature births, and infertility. The disease can also lead to a greater predisposition to HIV infection and cervical and prostate cancer. Metronidazole (MTZ) is a drug that treats human trichomoniasis. The data from studies involving human subjects are limited regarding MTZ use during pregnancy. In addition to the toxicity of the treatment, some isolates have become resistant to MTZ. Therefore, searching for new compounds active for treating trichomoniasis becomes necessary. In the present study, we report results obtained using new phospholipid analogs. Two cardanol-based compounds designated LDT117 and LDT134 were active against T. vaginalis with an IC
Found 
Found 

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GOST Copy
De Souza T. G. et al. Effects of Cardanol-Based Phospholipid Analogs on Trichomonas vaginalis // Experimental Parasitology. 2024. Vol. 266. p. 108839.
GOST all authors (up to 50) Copy
De Souza T. G., de Lucena Costa B., Holanda C. A., Romeiro L. A. S., de Souza W., Benchimol M. Effects of Cardanol-Based Phospholipid Analogs on Trichomonas vaginalis // Experimental Parasitology. 2024. Vol. 266. p. 108839.
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RIS Copy
TY - JOUR
DO - 10.1016/j.exppara.2024.108839
UR - https://linkinghub.elsevier.com/retrieve/pii/S0014489424001425
TI - Effects of Cardanol-Based Phospholipid Analogs on Trichomonas vaginalis
T2 - Experimental Parasitology
AU - De Souza, Tatiana Guinancio
AU - de Lucena Costa, Brenda
AU - Holanda, Cleonice Andrade
AU - Romeiro, L. A. S.
AU - de Souza, Wanderley
AU - Benchimol, Marlene
PY - 2024
DA - 2024/11/01
PB - Elsevier
SP - 108839
VL - 266
PMID - 39265884
SN - 0014-4894
SN - 1090-2449
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2024_De Souza,
author = {Tatiana Guinancio De Souza and Brenda de Lucena Costa and Cleonice Andrade Holanda and L. A. S. Romeiro and Wanderley de Souza and Marlene Benchimol},
title = {Effects of Cardanol-Based Phospholipid Analogs on Trichomonas vaginalis},
journal = {Experimental Parasitology},
year = {2024},
volume = {266},
publisher = {Elsevier},
month = {nov},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0014489424001425},
pages = {108839},
doi = {10.1016/j.exppara.2024.108839}
}