Il Farmaco

, volume 59 , issue 5 , pages 405-412

Cytotoxicity of furoxans: quantitative structure-activity relationships study

Mariana Boiani ¹

Hugo Cerecetto ¹

Mercedes Catalán González ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Departamento de Química Orgánica, Facultad de Química-Facultad de Ciencias, Iguá 4225, 11400 Montevideo, Uruguay. |

Publication type: Journal Article

Publication date: 2004-05-01

Elsevier

Il Farmaco

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ISSN: 0014827X

DOI: 10.1016/j.farmac.2003.12.011

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PubMed ID: 15120320

Drug Discovery

Pharmaceutical Science

Abstract

Furoxans are interesting biological active compounds. Recent studies demonstrate that they are cytotoxic under aerobic conditions. This paper shows that this cytotoxicity could be related with E(LUMO), calculated LogP and Mulliken charge on heterocycle nitrogen 2 calculated at ab initio level (3-21G* basis). It was possible to propose a tentative mechanism of cytotoxicity and structural modifications to modulate the cytotoxic potency of furoxan derivatives.

Found

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Fershtat Leonid

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h-index: 29

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

1 citation

Larin Alexander

PhD in Chemistry

45 publications, 760 citations, 16 reviews

h-index: 16

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

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1 citation

Stebletsova Irina

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Boiani M., Cerecetto H., González M. C. Cytotoxicity of furoxans: quantitative structure-activity relationships study // Il Farmaco. 2004. Vol. 59. No. 5. pp. 405-412.

GOST all authors (up to 50) Copy

Boiani M., Cerecetto H., González M. C. Cytotoxicity of furoxans: quantitative structure-activity relationships study // Il Farmaco. 2004. Vol. 59. No. 5. pp. 405-412.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.farmac.2003.12.011

UR - https://doi.org/10.1016/j.farmac.2003.12.011

TI - Cytotoxicity of furoxans: quantitative structure-activity relationships study

T2 - Il Farmaco

AU - Boiani, Mariana

AU - Cerecetto, Hugo

AU - González, Mercedes Catalán

PY - 2004

DA - 2004/05/01

PB - Elsevier

SP - 405-412

IS - 5

VL - 59

PMID - 15120320

SN - 0014-827X

ER -

BibTex |

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@article{2004_Boiani,

author = {Mariana Boiani and Hugo Cerecetto and Mercedes Catalán González},

title = {Cytotoxicity of furoxans: quantitative structure-activity relationships study},

journal = {Il Farmaco},

year = {2004},

volume = {59},

publisher = {Elsevier},

month = {may},

url = {https://doi.org/10.1016/j.farmac.2003.12.011},

number = {5},

pages = {405--412},

doi = {10.1016/j.farmac.2003.12.011}

}

MLA

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MLA Copy

Boiani, Mariana, et al. “Cytotoxicity of furoxans: quantitative structure-activity relationships study.” Il Farmaco, vol. 59, no. 5, May. 2004, pp. 405-412. https://doi.org/10.1016/j.farmac.2003.12.011.

Publisher

Elsevier

Journal

Il Farmaco

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—

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—

Impact factor

—

ISSN

0014827X (Print)