Hepatitis C virus NS5A protein modulates template selection by the RNA polymerase in in vitro system
А. В. Иванов
1, 2
,
Olga Ivanova
3
,
Vladimir A. Mitkevich
1, 2
,
VLADIMIR S. PRASSOLOV
3
,
Alexander A. Makarov
3
,
Marina Kukhanova
3
,
2
University of Oslo, Centre for Medical Study in Russia, Moscow 119334, Russia
|
Publication type: Journal Article
Publication date: 2008-12-13
scimago Q1
wos Q2
SJR: 1.222
CiteScore: 6.1
Impact factor: 3.0
ISSN: 00145793, 18733468
PubMed ID:
19073181
Biochemistry
Molecular Biology
Cell Biology
Genetics
Structural Biology
Biophysics
Abstract
Hepatitis C virus (HCV) NS5A phosphoprotein is a component of virus replicase. Here we demonstrate that in vitro unphosphorylated NS5A protein inhibits HCV RNA-dependent RNA polymerase (RdRp) activity in polyA-oligoU system but has little effect on synthesis of viral RNA. The phosphorylated casein kinase (CK) II NS5A protein causes the opposite effect on RdRp in each of these systems. The phosphorylation of NS5A protein with CKII does not affect its affinity to the HCV RdRp and RNA. The NS5A phosphorylation with CKI does not change the RdRp activity. Herein we report evidence that the NS5A prevents template binding to the RdRp.
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Total citations:
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Citations from 2024:
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GOST
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Иванов А. В. et al. Hepatitis C virus NS5A protein modulates template selection by the RNA polymerase in in vitro system // FEBS Letters. 2008. Vol. 583. No. 2. pp. 277-280.
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Иванов А. В., Tunitskaya V. L., Ivanova O., Mitkevich V. A., PRASSOLOV V. S., Makarov A. A., Kukhanova M., Кочетков С. Н. Hepatitis C virus NS5A protein modulates template selection by the RNA polymerase in in vitro system // FEBS Letters. 2008. Vol. 583. No. 2. pp. 277-280.
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RIS
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TY - JOUR
DO - 10.1016/j.febslet.2008.12.016
UR - https://doi.org/10.1016/j.febslet.2008.12.016
TI - Hepatitis C virus NS5A protein modulates template selection by the RNA polymerase in in vitro system
T2 - FEBS Letters
AU - Иванов, А. В.
AU - Tunitskaya, Vera L
AU - Ivanova, Olga
AU - Mitkevich, Vladimir A.
AU - PRASSOLOV, VLADIMIR S.
AU - Makarov, Alexander A.
AU - Kukhanova, Marina
AU - Кочетков, С. Н.
PY - 2008
DA - 2008/12/13
PB - Wiley
SP - 277-280
IS - 2
VL - 583
PMID - 19073181
SN - 0014-5793
SN - 1873-3468
ER -
Cite this
BibTex (up to 50 authors)
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@article{2008_Иванов,
author = {А. В. Иванов and Vera L Tunitskaya and Olga Ivanova and Vladimir A. Mitkevich and VLADIMIR S. PRASSOLOV and Alexander A. Makarov and Marina Kukhanova and С. Н. Кочетков},
title = {Hepatitis C virus NS5A protein modulates template selection by the RNA polymerase in in vitro system},
journal = {FEBS Letters},
year = {2008},
volume = {583},
publisher = {Wiley},
month = {dec},
url = {https://doi.org/10.1016/j.febslet.2008.12.016},
number = {2},
pages = {277--280},
doi = {10.1016/j.febslet.2008.12.016}
}
Cite this
MLA
Copy
Иванов, А. В., et al. “Hepatitis C virus NS5A protein modulates template selection by the RNA polymerase in in vitro system.” FEBS Letters, vol. 583, no. 2, Dec. 2008, pp. 277-280. https://doi.org/10.1016/j.febslet.2008.12.016.