Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review

Publication type: Journal Article
Publication date: 2025-06-07
Elsevier
scimago Q1
wos Q1
SJR: 1.444
CiteScore: 14.6
Impact factor: 6.3
ISSN: 26665549
Abstract
Hepatitis B virus (HBV) is a significant global health concern, characterized by its potential to cause acute and chronic liver diseases. Despite the availability of effective vaccines and treatments, substantial gaps remain in the management of chronic infections, particularly in regions like China, where millions are affected. This review delves into the synthesis of clinical anti-HBV drugs, including lamivudine, adefovir, tenofovir, entecavir, and telbivudine, highlighting various synthetic strategies. By emphasizing efficient synthetic routes suitable for large-scale production, this review contributes valuable insights for enhancing treatment accessibility and improving patient outcomes in hepatitis B management.
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Yao H. et al. Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review // Green Synthesis and Catalysis. 2025.
GOST all authors (up to 50) Copy
Yao H., Zheng X., Liu M., Xu Y., Xu P., Chen F. Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review // Green Synthesis and Catalysis. 2025.
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RIS Copy
TY - JOUR
DO - 10.1016/j.gresc.2025.06.001
UR - https://linkinghub.elsevier.com/retrieve/pii/S2666554925000626
TI - Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review
T2 - Green Synthesis and Catalysis
AU - Yao, Houzong
AU - Zheng, Xianjing
AU - Liu, Minjie
AU - Xu, Yuelun
AU - Xu, Ping
AU - Chen, Fen-Er
PY - 2025
DA - 2025/06/07
PB - Elsevier
SN - 2666-5549
ER -
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@article{2025_Yao,
author = {Houzong Yao and Xianjing Zheng and Minjie Liu and Yuelun Xu and Ping Xu and Fen-Er Chen},
title = {Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review},
journal = {Green Synthesis and Catalysis},
year = {2025},
publisher = {Elsevier},
month = {jun},
url = {https://linkinghub.elsevier.com/retrieve/pii/S2666554925000626},
doi = {10.1016/j.gresc.2025.06.001}
}