Open Access
Heliyon, volume 9, issue 2, pages e13446
Short- and long-term cognitive and metabolic effects of medium-chain triglyceride supplementation in rats
Shcherbakova Ksenia
1
,
Ivleva Irina S
3
,
Nikitina Veronika
1
,
Krytskaya Darya
1
,
Apryatin Sergey A.
1
,
Karpenko Marina N
3
,
Publication type: Journal Article
Publication date: 2023-02-06
PubMed ID:
36825166
Multidisciplinary
Abstract
Medium-chain triglycerides (MCT) possess neuroprotective properties. However, the long-term metabolic consequences of supplementing a regular diet with cognition-enhancing doses of MCT are largely unknown. We studied the effects of chronic (28 days) supplementation of regular diet with different doses of MCT oil (1, 3, or 6 g/kg/day) or water (control) on working memory (Y-maze), behavior in the Open Field, spatial learning (Morris water maze), and weight of internal organs in male Wistar 2.5-m.o. Rats. In a separate experiment, we evaluated acute (single gavage) and chronic (28 days) effects of MCT or lard supplementation (3 g/kg) on blood biochemical parameters. MCT-1 and MCT-3 doses improved working memory in YM. In MWM, MCT-6 treatment improved spatial memory. Chronic MCT-1 or MCT-3 treatment did not affect internal organ weight, while MCT-6 dose increased liver weight and the brown/white adipose tissue ratio. Acutely, MCT administration elevated blood β-hydroxybutyrate and malondialdehyde levels. Chronic MCT administration (3 g/kg) did not affect the blood levels of glucose, lactate, pyruvate, acetoacetate, β-hydroxybutyrate, total and HDL cholesterol, triglycerides, malondialdehyde, and aspartate transaminase and alanine transaminase activities. Therefore, daily supplementation of standard feed with MCT resulted in mild intermittent ketosis. It improved working memory at lower concentrations without significant adverse side effects. At higher concentrations, it improved long-term spatial memory but also resulted in organ weight changes and is likely unsafe. These results highlight the importance of monitoring the metabolic effects of MCT supplementation alongside cognitive assessment in future studies of MCT's neuroprotective properties.
Citations by journals
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1
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Journal of Neural Transmission
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Journal of Neural Transmission
1 publication, 50%
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Current Opinion in Clinical Nutrition and Metabolic Care
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Current Opinion in Clinical Nutrition and Metabolic Care
1 publication, 50%
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1
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Citations by publishers
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1
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Springer Nature
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Springer Nature
1 publication, 50%
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Wolters Kluwer Health
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Wolters Kluwer Health
1 publication, 50%
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1
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Shcherbakova K. et al. Short- and long-term cognitive and metabolic effects of medium-chain triglyceride supplementation in rats // Heliyon. 2023. Vol. 9. No. 2. p. e13446.
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Shcherbakova K., Schwarz A. P., Ivleva I. S., Nikitina V., Krytskaya D., Apryatin S. A., Karpenko M. N., Trofimov A. N. Short- and long-term cognitive and metabolic effects of medium-chain triglyceride supplementation in rats // Heliyon. 2023. Vol. 9. No. 2. p. e13446.
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TY - JOUR
DO - 10.1016/j.heliyon.2023.e13446
UR - https://doi.org/10.1016%2Fj.heliyon.2023.e13446
TI - Short- and long-term cognitive and metabolic effects of medium-chain triglyceride supplementation in rats
T2 - Heliyon
AU - Shcherbakova, Ksenia
AU - Schwarz, Alexander P
AU - Ivleva, Irina S
AU - Nikitina, Veronika
AU - Krytskaya, Darya
AU - Apryatin, Sergey A.
AU - Karpenko, Marina N
AU - Trofimov, Alexander N
PY - 2023
DA - 2023/02/06 00:00:00
PB - Elsevier
SP - e13446
IS - 2
VL - 9
PMID - 36825166
SN - 2405-8440
ER -
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@article{2023_Shcherbakova,
author = {Ksenia Shcherbakova and Alexander P Schwarz and Irina S Ivleva and Veronika Nikitina and Darya Krytskaya and Sergey A. Apryatin and Marina N Karpenko and Alexander N Trofimov},
title = {Short- and long-term cognitive and metabolic effects of medium-chain triglyceride supplementation in rats},
journal = {Heliyon},
year = {2023},
volume = {9},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016%2Fj.heliyon.2023.e13446},
number = {2},
pages = {e13446},
doi = {10.1016/j.heliyon.2023.e13446}
}
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Shcherbakova, Ksenia, et al. “Short- and long-term cognitive and metabolic effects of medium-chain triglyceride supplementation in rats.” Heliyon, vol. 9, no. 2, Feb. 2023, p. e13446. https://doi.org/10.1016%2Fj.heliyon.2023.e13446.