Non-symmetrically substituted N-heterocyclic carbene–Ag(I) complexes of benzimidazol-2-ylidenes: Synthesis, crystal structures, anticancer activity and transmetallation studies
Rosenani A. Haque
1
,
Mohammed Z. Ghdhayeb
1
,
Abbas Washeel Salman
1
,
Mohamed B. Khadeer Ahamed
2, 3, 4
,
AMS Abdul Majid
2, 3, 4
2
EMAN Research and Testing Laboratory, The School of Pharmaceutical Sciences
Publication type: Journal Article
Publication date: 2013-01-01
scimago Q3
wos Q2
SJR: 0.393
CiteScore: 5.5
Impact factor: 3.2
ISSN: 00201693, 18733255
Materials Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Abstract
Non-symmetrically substituted benzimidazolium salts (1 and 2) having bromide counterion undergo metallation with Ag2O at stiochiometric ratio, giving mononuclear bis-carbene Ag(I) complexes (3 and 4), active as anticancer agents against Human Colorectal (HCT 116) cell lines. Both the complexes provide good activity (IC50 = 13.9 μM for 3 and 14.6 μM for 4) in the anticancer studies and so distinctly better than the ligand precursors (IC50 = 119.3 μM for 1, and 70.0 μM for 2). The molecular structure of Ag complexes 3 and 4 is elucidated by X-ray diffraction studies. The Pd(II)– and Au(I)–NHC complexes (5 and 6) were synthesized from 4 via the technique of transmetallation. However, attempts to produce transmetallated complexes using 3 were unsuccessful.
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GOST
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Haque R. A. et al. Non-symmetrically substituted N-heterocyclic carbene–Ag(I) complexes of benzimidazol-2-ylidenes: Synthesis, crystal structures, anticancer activity and transmetallation studies // Inorganica Chimica Acta. 2013. Vol. 394. pp. 519-525.
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Haque R. A., Ghdhayeb M. Z., Budagumpi S., Salman A. W., Ahamed M. B. K., Abdul Majid A. Non-symmetrically substituted N-heterocyclic carbene–Ag(I) complexes of benzimidazol-2-ylidenes: Synthesis, crystal structures, anticancer activity and transmetallation studies // Inorganica Chimica Acta. 2013. Vol. 394. pp. 519-525.
Cite this
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TY - JOUR
DO - 10.1016/j.ica.2012.09.013
UR - https://doi.org/10.1016/j.ica.2012.09.013
TI - Non-symmetrically substituted N-heterocyclic carbene–Ag(I) complexes of benzimidazol-2-ylidenes: Synthesis, crystal structures, anticancer activity and transmetallation studies
T2 - Inorganica Chimica Acta
AU - Haque, Rosenani A.
AU - Ghdhayeb, Mohammed Z.
AU - Budagumpi, Srinivasa
AU - Salman, Abbas Washeel
AU - Ahamed, Mohamed B. Khadeer
AU - Abdul Majid, AMS
PY - 2013
DA - 2013/01/01
PB - Elsevier
SP - 519-525
VL - 394
SN - 0020-1693
SN - 1873-3255
ER -
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@article{2013_Haque,
author = {Rosenani A. Haque and Mohammed Z. Ghdhayeb and Srinivasa Budagumpi and Abbas Washeel Salman and Mohamed B. Khadeer Ahamed and AMS Abdul Majid},
title = {Non-symmetrically substituted N-heterocyclic carbene–Ag(I) complexes of benzimidazol-2-ylidenes: Synthesis, crystal structures, anticancer activity and transmetallation studies},
journal = {Inorganica Chimica Acta},
year = {2013},
volume = {394},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.ica.2012.09.013},
pages = {519--525},
doi = {10.1016/j.ica.2012.09.013}
}