Inorganica Chimica Acta, volume 528, pages 120601
Synthesis, characterization, HSA/DNA binding, cytotoxicity study, and antimicrobial activity of new palladium(II) complexes with some esters of (S,S)-propylenediamine-N,N'-di-2-(3-methyl)butanoic acid
Đorđe S Petrović
1
,
Sandra S Jovičić Milić
1
,
Maja B Đukić
1
,
Ivana Radojevic
2
,
Ratomir Jelić
3
,
Milena M Jurisevic
3
,
Gordana P. Radić
3
,
Nevena M Gajovic
4
,
Nebojsa N Arsenijevic
4
,
Ivan Jovanović
4
,
Nenad V Markovic
5
,
Dejan Stojković
6
,
Verica V Jevtić
1
1
University of Kragujevac Faculty of Science Department of Chemistry Radoja Domanovića 12 34000 Kragujevac Republic of Serbia
|
2
University of Kragujevac, Faculty of Science, Department of Biology and Ecology, Radoja Domanovića 12, 34000 Kragujevac, Republic of Serbia
|
3
University of Kragujevac, Faculty of Medical Sciences, Department of Pharmacy, Svetozara Markovića 69, 34000 Kragujevac, Republic of Serbia
|
4
University of Kragujevac, Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research, Svetozara Markovića 69, 34000 Kragujevac, Republic of Serbia
|
5
University of Kragujevac, Faculty of Medical Sciences, Department of Surgery, Svetozara Markovića 69, 34000 Kragujevac, Republic of Serbia
|
6
University for Kragujevac, Institute of Information Technologies, Department of Science, Jovana Cvijića bb, 34000 Kragujevac, Republic of Serbia
|
Publication type: Journal Article
Publication date: 2021-12-01
Journal:
Inorganica Chimica Acta
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 2.8
ISSN: 00201693, 18733255
Materials Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Abstract
• New ligands and corresponding palladium(II) complexes were synthesized. • Characterization was performed by IR, 1 H and 13 C NMR spectroscopy. • The interactions of new complexes with CT-DNA and HSA were investigated. • In vitro cytotoxic activity of these ligands and complexes were evaluated. • Antimicrobial activity of ligands and complexes were investigated. In this paper, we presented synthesis, characterization, HSA/DNA binding evaluation, in vitro cytotoxic activity and in vitro antimicrobial activity of three new ligands of general formula. R 2 - S,S -pddmb ( L1 - L3 ) and their corresponding palladium(II) complexes of general formula [PdCl 2 (R 2 - S,S -pddmb)] (R = n -propyl, n -butyl, n -pentyl; S,S -pddmb = ( S,S )-propylenediamine- N,N'- di-2-(3-methyl)-butanoate). Ligands and complexes were characterized by elemental microanalysis, infrared, 1 H and 13 C NMR spectroscopy. The interactions of new palladium(II) complexes with human serum albumin (HSA) and calf thymus DNA (CT-DNA) were investigated using UV–Vis absorption and fluorescence spectroscopy. The high values of the binding constant, K b , and the Stern-Volmer quenching constant, K SV , are the result of good binding of all complexes to HSA and CT-DNA. In vitro cytotoxic activity of these ligands and complexes was evaluated against four tumor cell lines, 4 T1, CT26, MDA-MD-468, HCT116 and mesenchymal stem cells (mMSC). C3 complex showed high cytotoxic activity against MDA-MD-468 cell line. Flow cytometry analysis showed that L3 ligand and the corresponding complex (C3) stimulated apoptosis of tumor cells via inhibition of expression of antiapoptotic Bcl-2 molecule. L3 ligand and C3 complex slowed down cell proliferation and arrested tumor cell in the G0/G1 phase by decreasing Cyclin-D expression and by increasing expression of P21. In vitro antimicrobial activity of ligands and complexes was also investigated. The testing was performed by microdilution method and minimum inhibitory concentration (MIC) and minimum microbicidal concentration (MMC) were determined. The testing was conducted against 12 microorganisms. The tested ligands and palladium(II) complexes showed selective and moderate activity.
Top-30
Citations by journals
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1
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Langmuir
1 publication, 20%
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Journal of Inorganic Biochemistry
1 publication, 20%
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Russian Chemical Reviews
1 publication, 20%
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Dalton Transactions
1 publication, 20%
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1
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Citations by publishers
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1
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American Chemical Society (ACS)
1 publication, 20%
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Elsevier
1 publication, 20%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 20%
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Royal Society of Chemistry (RSC)
1 publication, 20%
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1
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Petrović Đ. S. et al. Synthesis, characterization, HSA/DNA binding, cytotoxicity study, and antimicrobial activity of new palladium(II) complexes with some esters of (S,S)-propylenediamine-N,N'-di-2-(3-methyl)butanoic acid // Inorganica Chimica Acta. 2021. Vol. 528. p. 120601.
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Petrović Đ. S., Milić S. S. J., Đukić M. B., Radojevic I., Jelić R., Jurisevic M. M., Radić G. P., Gajovic N. M., Arsenijevic N. N., Jovanović I., Markovic N. V., Stojković D., Jevtić V. V. Synthesis, characterization, HSA/DNA binding, cytotoxicity study, and antimicrobial activity of new palladium(II) complexes with some esters of (S,S)-propylenediamine-N,N'-di-2-(3-methyl)butanoic acid // Inorganica Chimica Acta. 2021. Vol. 528. p. 120601.
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TY - JOUR
DO - 10.1016/j.ica.2021.120601
UR - https://doi.org/10.1016/j.ica.2021.120601
TI - Synthesis, characterization, HSA/DNA binding, cytotoxicity study, and antimicrobial activity of new palladium(II) complexes with some esters of (S,S)-propylenediamine-N,N'-di-2-(3-methyl)butanoic acid
T2 - Inorganica Chimica Acta
AU - Petrović, Đorđe S
AU - Milić, Sandra S Jovičić
AU - Đukić, Maja B
AU - Radojevic, Ivana
AU - Jelić, Ratomir
AU - Jurisevic, Milena M
AU - Radić, Gordana P.
AU - Gajovic, Nevena M
AU - Arsenijevic, Nebojsa N
AU - Jovanović, Ivan
AU - Markovic, Nenad V
AU - Stojković, Dejan
AU - Jevtić, Verica V
PY - 2021
DA - 2021/12/01 00:00:00
PB - Elsevier
SP - 120601
VL - 528
SN - 0020-1693
SN - 1873-3255
ER -
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@article{2021_Petrović,
author = {Đorđe S Petrović and Sandra S Jovičić Milić and Maja B Đukić and Ivana Radojevic and Ratomir Jelić and Milena M Jurisevic and Gordana P. Radić and Nevena M Gajovic and Nebojsa N Arsenijevic and Ivan Jovanović and Nenad V Markovic and Dejan Stojković and Verica V Jevtić},
title = {Synthesis, characterization, HSA/DNA binding, cytotoxicity study, and antimicrobial activity of new palladium(II) complexes with some esters of (S,S)-propylenediamine-N,N'-di-2-(3-methyl)butanoic acid},
journal = {Inorganica Chimica Acta},
year = {2021},
volume = {528},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.ica.2021.120601},
pages = {120601},
doi = {10.1016/j.ica.2021.120601}
}