International Journal of Hygiene and Environmental Health, volume 243, pages 113977
Urinary phthalate metabolite concentrations during four windows spanning puberty (prepuberty through sexual maturity) and association with semen quality among young Russian men
Mínguez-Alarcón Lidia
1, 2
,
Burns Jane
1
,
Williams Paige L
3, 4
,
Korrick S A
1, 2
,
Lee Mary M
5, 6
,
Bather Jemar R
3
,
Kovalev S. V.
7
,
Sokolov S. A.
7
,
Smigulina Luidmila
8, 9
,
Abou-Ghayda Ramy
10
,
Koch Holger
11
,
Sergeyev Oleg
8, 9
,
Hauser R
1, 12
1
Departments of Environmental Health, Boston, USA
|
2
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital & Harvard Medical School, Boston, USA
|
3
Departments of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, USA
|
4
Departments of Epidemiology and Boston, USA
|
5
Nemours Children's Health, Wilmington, DE, USA
|
6
Department of Pediatrics, Sidney Kimmel Medical College, Philadelphia, PA, USA
|
8
Chapaevsk Medical Association, Chapaevsk, Russia
|
10
Division of Urology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
|
11
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance - Institute of the Ruhr-University Bochum (IPA), Bochum, Germany
|
12
Department of Obstetrics, Gynecology and Reproductive Medicine, Harvard Medical School, Boston, USA
|
Publication type: Journal Article
Publication date: 2022-06-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6
ISSN: 14384639
Public Health, Environmental and Occupational Health
Abstract
To prospectively investigate the associations of urinary phthalate metabolite concentrations measured at four time points spanning pubertal development with semen parameters in Russian men. 516 boys were enrolled at ages 8–9 years (2003–2005) and followed annually. Urine samples were collected annually and pooled into four exposure windows [prepuberty, early puberty, late puberty and sexual maturity] based on physician assessed Tanner genitalia stages and testicular volume. Fifteen phthalate metabolites were quantified using isotope dilution HPLC-MS/MS at Moscow State University. We calculated molar sums (∑) of di-2-ethylhexyl phthalate (DEHP), di-isononyl phthalate (DiNP), di-isodecyl phthalate (DiDP) and anti-androgenic phthalate (AAP) metabolites. At sexual maturity (ages 18–19 years), the men provided 1–2 semen samples for analysis. We estimated the associations of quintiles of urinary ∑phthalate metabolites as well as mono-butyl phthalate (MnBP), mono-isobutyl phthalate (MiBP), and mono-benzyl phthalate (MBzP) at each pubertal window, with semen parameters by fitting generalized linear mixed models with random intercepts and adjusting for confounders . A total of 223 men who provided semen samples had phthalates measured at one or more pubertal windows. Higher urinary concentrations of ∑DiNP metabolites during late puberty were related to poorer semen quality (men with the highest quintile of urinary ∑DiNP had 30% lower sperm concentration, 32% lower count and 30% lower progressive motile count, compared to men in the lowest quintile). Also, young men with higher urinary concentrations of MiBP metabolites in early puberty tended to have poorer semen quality. No associations were observed for ∑DEHP metabolites, ∑DiDP metabolites, ∑AAP, MBzP or MnBP metabolites with semen quality parameters. ∑DiNP metabolites measured during late puberty and MiBP metabolites at early puberty were related to poorer semen quality, highlighting the importance of considering specific windows of exposure when investigating chemical exposures in relation to measures of reproductive health in men.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Mínguez-Alarcón L. et al. Urinary phthalate metabolite concentrations during four windows spanning puberty (prepuberty through sexual maturity) and association with semen quality among young Russian men // International Journal of Hygiene and Environmental Health. 2022. Vol. 243. p. 113977.
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Mínguez-Alarcón L., Burns J., Williams P. L., Korrick S. A., Lee M. M., Bather J. R., Kovalev S. V., Sokolov S. A., Lebedev A. T., Smigulina L., Abou-Ghayda R., Koch H., Sergeyev O., Hauser R. Urinary phthalate metabolite concentrations during four windows spanning puberty (prepuberty through sexual maturity) and association with semen quality among young Russian men // International Journal of Hygiene and Environmental Health. 2022. Vol. 243. p. 113977.
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TY - JOUR
DO - 10.1016/j.ijheh.2022.113977
UR - https://doi.org/10.1016%2Fj.ijheh.2022.113977
TI - Urinary phthalate metabolite concentrations during four windows spanning puberty (prepuberty through sexual maturity) and association with semen quality among young Russian men
T2 - International Journal of Hygiene and Environmental Health
AU - Mínguez-Alarcón, Lidia
AU - Burns, Jane
AU - Williams, Paige L
AU - Korrick, S A
AU - Lee, Mary M
AU - Bather, Jemar R
AU - Kovalev, S. V.
AU - Sokolov, S. A.
AU - Lebedev, Albert T.
AU - Smigulina, Luidmila
AU - Abou-Ghayda, Ramy
AU - Koch, Holger
AU - Sergeyev, Oleg
AU - Hauser, R
PY - 2022
DA - 2022/06/01 00:00:00
PB - Elsevier
SP - 113977
VL - 243
SN - 1438-4639
ER -
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@article{2022_Mínguez-Alarcón,
author = {Lidia Mínguez-Alarcón and Jane Burns and Paige L Williams and S A Korrick and Mary M Lee and Jemar R Bather and S. V. Kovalev and S. A. Sokolov and Albert T. Lebedev and Luidmila Smigulina and Ramy Abou-Ghayda and Holger Koch and Oleg Sergeyev and R Hauser},
title = {Urinary phthalate metabolite concentrations during four windows spanning puberty (prepuberty through sexual maturity) and association with semen quality among young Russian men},
journal = {International Journal of Hygiene and Environmental Health},
year = {2022},
volume = {243},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016%2Fj.ijheh.2022.113977},
pages = {113977},
doi = {10.1016/j.ijheh.2022.113977}
}