Open Access

International Journal of Pharmaceutics

, volume 485 , issue 1-2 , pages 357-364

Self-assembled filomicelles prepared from polylactide/poly(ethylene glycol) block copolymers for anticancer drug delivery

Katarzyna Jelonek ¹

Shan-Ming Hsu ²

Xiaohan Wu ³

Andrzej Marcinkowski ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Curie-Sklodowska 34 Street, 41-819 Zabrze, Poland |

European Institute of Membranes, UMR CNRS 5635, University Montpellier 2, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France |

Max Mousseron Institute on Biomolecules, UMR CNRS 5247, University Montpellier 1, 34090 Montpellier Cedex 5, France |

Publication type: Journal Article

Publication date: 2015-05-01

Elsevier

International Journal of Pharmaceutics

scimago Q1

wos Q1

SJR: 0.988

CiteScore: 10.1

Impact factor: 5.2

ISSN: 03785173, 18733476

DOI: 10.1016/j.ijpharm.2015.03.032

Copy DOI

PubMed ID: 25796125

Pharmaceutical Science

Abstract

Bioresorbable filomicelles present many advantageous as drug delivery systems e.g., long circulation time and high loading efficiency. The aim of this study was to develop polylactide/poly(ethylene glycol) (PLA/PEG) filomicelles for drug delivery applications. A series of PLA/PEG diblock copolymers were synthesized using non-toxic initiator, and characterized by means of NMR and GPC. Analysis of morphology of micelles determined by TEM revealed that apart from the weight fraction also the molar mass of PEG and the stereochemistry of PLA block must be considered for tailoring micellar structures. The CMC was found to be dependent on the length and structure of the hydrophobic block. It was observed that the drug loading properties could be improved by selection of appropriate copolymer and encapsulation method. Slower release of paclitaxel was observed for mPEG5000 initiated copolymers than mPEG2000 initiated copolymers. Moreover, the influence of the length of hydrophobic block and its stereoisomeric form on drug release rate was evidenced. Therefore, PLA/PEG filomicelles with good stability, high drug loading capacity and sustained drug release appear most attractive for drug delivery applications.

Found

1 citation

Bakirov Artem

🤝

PhD in Physics and Mathematics

117 publications, 1 561 citations, 18 reviews

h-index: 21

Enikolopov Institute of Synthetic Polymeric Materials of the Russian Academy of Sciences

National Research Centre "Kurchatov Institute"

Research interests

Dendrimers

High molecular weight compounds

Nanocomposites

Nanomaterials

Physics of polymers

Self-healing polymers

Small-angle X-ray scattering (Small-angle X-ray scattering)

X-ray diffraction (XRD)

X-ray diffraction analysis

1 citation

Dmitryakov Petr

46 publications, 485 citations

h-index: 11

National Research Centre "Kurchatov Institute"

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GOST |

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GOST Copy

Jelonek K. et al. Self-assembled filomicelles prepared from polylactide/poly(ethylene glycol) block copolymers for anticancer drug delivery // International Journal of Pharmaceutics. 2015. Vol. 485. No. 1-2. pp. 357-364.

GOST all authors (up to 50) Copy

Jelonek K., Hsu S., Wu X., Marcinkowski A. Self-assembled filomicelles prepared from polylactide/poly(ethylene glycol) block copolymers for anticancer drug delivery // International Journal of Pharmaceutics. 2015. Vol. 485. No. 1-2. pp. 357-364.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.ijpharm.2015.03.032

UR - https://linkinghub.elsevier.com/retrieve/pii/S0378517315002483

TI - Self-assembled filomicelles prepared from polylactide/poly(ethylene glycol) block copolymers for anticancer drug delivery

T2 - International Journal of Pharmaceutics

AU - Jelonek, Katarzyna

AU - Hsu, Shan-Ming

AU - Wu, Xiaohan

AU - Marcinkowski, Andrzej

PY - 2015

DA - 2015/05/01

PB - Elsevier

SP - 357-364

IS - 1-2

VL - 485

PMID - 25796125

SN - 0378-5173

SN - 1873-3476

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2015_Jelonek,

author = {Katarzyna Jelonek and Shan-Ming Hsu and Xiaohan Wu and Andrzej Marcinkowski},

title = {Self-assembled filomicelles prepared from polylactide/poly(ethylene glycol) block copolymers for anticancer drug delivery},

journal = {International Journal of Pharmaceutics},

year = {2015},

volume = {485},

publisher = {Elsevier},

month = {may},

url = {https://linkinghub.elsevier.com/retrieve/pii/S0378517315002483},

number = {1-2},

pages = {357--364},

doi = {10.1016/j.ijpharm.2015.03.032}

}

MLA

Cite this

MLA Copy

Jelonek, Katarzyna, et al. “Self-assembled filomicelles prepared from polylactide/poly(ethylene glycol) block copolymers for anticancer drug delivery.” International Journal of Pharmaceutics, vol. 485, no. 1-2, May. 2015, pp. 357-364. https://linkinghub.elsevier.com/retrieve/pii/S0378517315002483.

Publisher

Elsevier

Journal

International Journal of Pharmaceutics

scimago Q1

wos Q1

SJR

0.988

CiteScore

10.1

Impact factor

5.2

ISSN

03785173 (Print)

18733476 (Electronic)