том 43 издание 3 страницы 210-229

Unraveling B cell trajectories at single cell resolution

Тип публикацииJournal Article
Дата публикации2022-03-01
scimago Q1
wos Q1
white level БС1
SJR3.895
CiteScore21.2
Impact factor13.9
ISSN14714906, 14714981
Immunology
Immunology and Allergy
Краткое описание
During adaptive immunity, B cells differentiate either into memory B cells or plasma cells and produce antibodies against foreign antigens to fight infection. Additionally, they behave as antigen-presenting cells and participate in T cell activation during cellular immune responses. However, their functional dysregulation can result in various autoimmune diseases and cancers. With significant breakthroughs in single cell technologies, assessing individual B cell genomics, transcriptomics, and proteomics can give deeper insights into mammalian B cell development, differentiation, antibody repertoire, and responses under conditions of homeostasis, infection, and aberrations during disease. In this review, we discuss the adoption of single cell approaches to identify different B cell gene signatures and biomarkers in normal and diseased tissues, and subsequent benefits for future therapeutic discoveries.
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ГОСТ |
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Morgan D. et al. Unraveling B cell trajectories at single cell resolution // Trends in Immunology. 2022. Vol. 43. No. 3. pp. 210-229.
ГОСТ со всеми авторами (до 50) Скопировать
Morgan D., Tergaonkar V. Unraveling B cell trajectories at single cell resolution // Trends in Immunology. 2022. Vol. 43. No. 3. pp. 210-229.
RIS |
Цитировать
TY - JOUR
DO - 10.1016/j.it.2022.01.003
UR - https://doi.org/10.1016/j.it.2022.01.003
TI - Unraveling B cell trajectories at single cell resolution
T2 - Trends in Immunology
AU - Morgan, Dhakshayini
AU - Tergaonkar, V.
PY - 2022
DA - 2022/03/01
PB - Elsevier
SP - 210-229
IS - 3
VL - 43
PMID - 35090788
SN - 1471-4906
SN - 1471-4981
ER -
BibTex |
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BibTex (до 50 авторов) Скопировать
@article{2022_Morgan,
author = {Dhakshayini Morgan and V. Tergaonkar},
title = {Unraveling B cell trajectories at single cell resolution},
journal = {Trends in Immunology},
year = {2022},
volume = {43},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.it.2022.01.003},
number = {3},
pages = {210--229},
doi = {10.1016/j.it.2022.01.003}
}
MLA
Цитировать
Morgan, Dhakshayini, et al. “Unraveling B cell trajectories at single cell resolution.” Trends in Immunology, vol. 43, no. 3, Mar. 2022, pp. 210-229. https://doi.org/10.1016/j.it.2022.01.003.
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