PEG-modified gold nanorods with a stealth character for in vivo applications.
Takuro Niidome
1
,
Masato Yamagata
2
,
Yuri Okamoto
2
,
Yasuyuki AKIYAMA
2
,
Hironobu Takahashi
2
,
Takahito Kawano
1
,
Yoshiki Katayama
3
,
Yasuro Niidome
2
Publication type: Journal Article
Publication date: 2006-09-01
scimago Q1
wos Q1
SJR: 2.470
CiteScore: 19.4
Impact factor: 11.5
ISSN: 01683659, 18734995
PubMed ID:
16876898
Pharmaceutical Science
Abstract
Gold nanorods prepared in hexadecyltrimethylammonium bromide (CTAB) solution are expected to provide novel materials for photothermal therapy and photo-controlled drug delivery systems. Since gold nanorods stabilized with CTAB show strong cytotoxicity, we developed a technique to modify these with polyethyleneglycol (PEG) for medical applications. PEG-modification was achieved by adding mPEG-SH in the CTAB solution, then, excess CTAB was removed by dialysis. PEG-modified gold nanoparticles showed a nearly neutral surface, and had little cytotoxicity in vitro. Following intravenous injection into mice, 54% of injected PEG-modified gold nanoparticles were found in blood at 0.5 h after intravenous injection, whereas most of gold was detected in the liver in the case of original gold nanorods stabilized with CTAB.
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Total citations:
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Niidome T. et al. PEG-modified gold nanorods with a stealth character for in vivo applications. // Journal of Controlled Release. 2006. Vol. 114. No. 3. pp. 343-347.
GOST all authors (up to 50)
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Niidome T., Yamagata M., Okamoto Y., AKIYAMA Y., Takahashi H., Kawano T., Katayama Y., Niidome Y. PEG-modified gold nanorods with a stealth character for in vivo applications. // Journal of Controlled Release. 2006. Vol. 114. No. 3. pp. 343-347.
Cite this
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TY - JOUR
DO - 10.1016/j.jconrel.2006.06.017
UR - https://doi.org/10.1016/j.jconrel.2006.06.017
TI - PEG-modified gold nanorods with a stealth character for in vivo applications.
T2 - Journal of Controlled Release
AU - Niidome, Takuro
AU - Yamagata, Masato
AU - Okamoto, Yuri
AU - AKIYAMA, Yasuyuki
AU - Takahashi, Hironobu
AU - Kawano, Takahito
AU - Katayama, Yoshiki
AU - Niidome, Yasuro
PY - 2006
DA - 2006/09/01
PB - Elsevier
SP - 343-347
IS - 3
VL - 114
PMID - 16876898
SN - 0168-3659
SN - 1873-4995
ER -
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BibTex (up to 50 authors)
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@article{2006_Niidome,
author = {Takuro Niidome and Masato Yamagata and Yuri Okamoto and Yasuyuki AKIYAMA and Hironobu Takahashi and Takahito Kawano and Yoshiki Katayama and Yasuro Niidome},
title = {PEG-modified gold nanorods with a stealth character for in vivo applications.},
journal = {Journal of Controlled Release},
year = {2006},
volume = {114},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/j.jconrel.2006.06.017},
number = {3},
pages = {343--347},
doi = {10.1016/j.jconrel.2006.06.017}
}
Cite this
MLA
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Niidome, Takuro, et al. “PEG-modified gold nanorods with a stealth character for in vivo applications..” Journal of Controlled Release, vol. 114, no. 3, Sep. 2006, pp. 343-347. https://doi.org/10.1016/j.jconrel.2006.06.017.