Macromolecular therapeutics in cancer treatment: The EPR effect and beyond
Тип публикации: Journal Article
Дата публикации: 2012-12-01
scimago Q1
wos Q1
БС1
SJR: 2.47
CiteScore: 19.4
Impact factor: 11.5
ISSN: 01683659, 18734995
PubMed ID:
22595146
Pharmaceutical Science
Краткое описание
In this review, I have discussed various issues of the cancer drug targeting primarily related to the EPR (enhanced permeability and retention) effect, which utilized nanomedicine or macromolecular drugs. The content goes back to the development of the first polymer-protein conjugate anticancer agent SMANCS and development of the arterial infusion in Lipiodol formulation into the tumor feeding artery (hepatic artery for hepatoma). The brief account on the EPR effect and its definition, factors involved, heterogeneity, and various methods of augmentation of the EPR effect, which showed remarkably improved clinical outcomes are also discussed. Various obstacles involved in drug developments and commercialization are also discussed through my personal experience and recollections.
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MAEDA H. Macromolecular therapeutics in cancer treatment: The EPR effect and beyond // Journal of Controlled Release. 2012. Vol. 164. No. 2. pp. 138-144.
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MAEDA H. Macromolecular therapeutics in cancer treatment: The EPR effect and beyond // Journal of Controlled Release. 2012. Vol. 164. No. 2. pp. 138-144.
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TY - JOUR
DO - 10.1016/j.jconrel.2012.04.038
UR - https://doi.org/10.1016/j.jconrel.2012.04.038
TI - Macromolecular therapeutics in cancer treatment: The EPR effect and beyond
T2 - Journal of Controlled Release
AU - MAEDA, Hiroshi
PY - 2012
DA - 2012/12/01
PB - Elsevier
SP - 138-144
IS - 2
VL - 164
PMID - 22595146
SN - 0168-3659
SN - 1873-4995
ER -
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@article{2012_MAEDA,
author = {Hiroshi MAEDA},
title = {Macromolecular therapeutics in cancer treatment: The EPR effect and beyond},
journal = {Journal of Controlled Release},
year = {2012},
volume = {164},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.jconrel.2012.04.038},
number = {2},
pages = {138--144},
doi = {10.1016/j.jconrel.2012.04.038}
}
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MLA
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MAEDA, Hiroshi. “Macromolecular therapeutics in cancer treatment: The EPR effect and beyond.” Journal of Controlled Release, vol. 164, no. 2, Dec. 2012, pp. 138-144. https://doi.org/10.1016/j.jconrel.2012.04.038.