Non-viral vectors for RNA delivery
Publication type: Journal Article
Publication date: 2022-02-01
scimago Q1
wos Q1
SJR: 2.470
CiteScore: 19.4
Impact factor: 11.5
ISSN: 01683659, 18734995
PubMed ID:
35016918
Pharmaceutical Science
Abstract
RNA-based therapy is a promising and potential strategy for disease treatment by introducing exogenous nucleic acids such as messenger RNA (mRNA), small interfering RNA (siRNA), microRNA (miRNA) or antisense oligonucleotides (ASO) to modulate gene expression in specific cells. It is exciting that mRNA encoding the spike protein of COVID-19 (coronavirus disease 2019) delivered by lipid nanoparticles (LNPs) exhibits the efficient protection of lungs infection against the virus. In this review, we introduce the biological barriers to RNA delivery in vivo and discuss recent advances in non-viral delivery systems, such as lipid-based nanoparticles, polymeric nanoparticles, N -acetylgalactosamine (GalNAc)-siRNA conjugate, and biomimetic nanovectors, which can protect RNAs against degradation by ribonucleases, accumulate in specific tissue, facilitate cell internalization, and allow for the controlled release of the encapsulated therapeutics.
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Metrics
269
Total citations:
269
Citations from 2025:
95
(35.32%)
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GOST
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Yan Y. et al. Non-viral vectors for RNA delivery // Journal of Controlled Release. 2022. Vol. 342. pp. 241-279.
GOST all authors (up to 50)
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Yan Y., Liu X., AN L., Wang X., Jiang L. X., Wang J. Non-viral vectors for RNA delivery // Journal of Controlled Release. 2022. Vol. 342. pp. 241-279.
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RIS
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TY - JOUR
DO - 10.1016/j.jconrel.2022.01.008
UR - https://doi.org/10.1016/j.jconrel.2022.01.008
TI - Non-viral vectors for RNA delivery
T2 - Journal of Controlled Release
AU - Yan, Yi
AU - Liu, Xiaoyu
AU - AN, LU
AU - Wang, Xinghui
AU - Jiang, Lin Xia
AU - Wang, Jian-cheng
PY - 2022
DA - 2022/02/01
PB - Elsevier
SP - 241-279
VL - 342
PMID - 35016918
SN - 0168-3659
SN - 1873-4995
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Yan,
author = {Yi Yan and Xiaoyu Liu and LU AN and Xinghui Wang and Lin Xia Jiang and Jian-cheng Wang},
title = {Non-viral vectors for RNA delivery},
journal = {Journal of Controlled Release},
year = {2022},
volume = {342},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.jconrel.2022.01.008},
pages = {241--279},
doi = {10.1016/j.jconrel.2022.01.008}
}