Nanoparticle-loaded gels for topical delivery of nitrofurazone: Effect of particle size on skin permeation and retention
1
Department of Pharmacy, Air Force General Hospital, PLA, Beijing 100142, China
|
Publication type: Journal Article
Publication date: 2018-06-01
scimago Q1
wos Q1
SJR: 0.817
CiteScore: 8.3
Impact factor: 4.9
ISSN: 17732247, 25888943, 11571489
Pharmaceutical Science
Abstract
In this study, the effect of particle size on skin permeation and retention of nitrofurazone (NTZ) from nanoparticle-loaded gels (NP-gels) was investigated to identify the suitable particle size of NTZ nanoparticle for topical delivery in order to achieve high deposition and low permeation of NTZ in the skin. NTZ nanosuspensions (NTZ-NSs) with three different particle size (299, 611, 906 nm) were prepared using wet media milling technique by adjusting milling speed and milling time, and then incorporated in carbopol gels for topical application. SEM and XRPD results showed that NTZ nanoparticles were well encapsulated in the gels network. The dissolution and the skin permeation of NTZ from NP-gels were particle size dependent and in an order of 299 nm > 611 nm > 906 nm, however, the skin deposition was in the order of 611 nm > 299 nm > 906 nm. The results demonstrated that the skin permeation and retention of NTZ from NP-gels were particle size dependent and the optimal size range was around 611 nm for topical application.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
5
|
|
|
Journal of Drug Delivery Science and Technology
5 publications, 11.63%
|
|
|
International Journal of Nanomedicine
3 publications, 6.98%
|
|
|
Gels
3 publications, 6.98%
|
|
|
International Journal of Pharmaceutics
2 publications, 4.65%
|
|
|
Journal of Pharmaceutical Sciences
2 publications, 4.65%
|
|
|
Pharmacia
2 publications, 4.65%
|
|
|
Journal of Biomedical Nanotechnology
1 publication, 2.33%
|
|
|
Chemistry Africa
1 publication, 2.33%
|
|
|
Journal of Pharmaceutical Innovation
1 publication, 2.33%
|
|
|
European Journal of Pharmaceutics and Biopharmaceutics
1 publication, 2.33%
|
|
|
Colloids and Surfaces B: Biointerfaces
1 publication, 2.33%
|
|
|
Environmental Pollution
1 publication, 2.33%
|
|
|
Drug Discovery Today
1 publication, 2.33%
|
|
|
ACS Applied Bio Materials
1 publication, 2.33%
|
|
|
Drug Development and Industrial Pharmacy
1 publication, 2.33%
|
|
|
Mendeleev Communications
1 publication, 2.33%
|
|
|
Journal of Cosmetic Dermatology
1 publication, 2.33%
|
|
|
Polymers and Polymer Composites
1 publication, 2.33%
|
|
|
Powder Technology
1 publication, 2.33%
|
|
|
Colloids and Surfaces A: Physicochemical and Engineering Aspects
1 publication, 2.33%
|
|
|
Biomaterials Advances
1 publication, 2.33%
|
|
|
ACS Omega
1 publication, 2.33%
|
|
|
Journal of Parasitic Diseases
1 publication, 2.33%
|
|
|
Environmental Technology and Innovation
1 publication, 2.33%
|
|
|
Current Cosmetic Science
1 publication, 2.33%
|
|
|
Biomedical and Pharmacology Journal
1 publication, 2.33%
|
|
|
AAPS Introductions in the Pharmaceutical Sciences
1 publication, 2.33%
|
|
|
Environmental Science Advances
1 publication, 2.33%
|
|
|
Contact Dermatitis
1 publication, 2.33%
|
|
|
1
2
3
4
5
|
Publishers
|
2
4
6
8
10
12
14
16
18
|
|
|
Elsevier
18 publications, 41.86%
|
|
|
Springer Nature
6 publications, 13.95%
|
|
|
Taylor & Francis
4 publications, 9.3%
|
|
|
MDPI
3 publications, 6.98%
|
|
|
American Chemical Society (ACS)
2 publications, 4.65%
|
|
|
Wiley
2 publications, 4.65%
|
|
|
Pensoft Publishers
2 publications, 4.65%
|
|
|
American Scientific Publishers
1 publication, 2.33%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 2.33%
|
|
|
SAGE
1 publication, 2.33%
|
|
|
Bentham Science Publishers Ltd.
1 publication, 2.33%
|
|
|
Oriental Scientific Publishing Company
1 publication, 2.33%
|
|
|
Royal Society of Chemistry (RSC)
1 publication, 2.33%
|
|
|
2
4
6
8
10
12
14
16
18
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
43
Total citations:
43
Citations from 2025:
14
(32.56%)
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Liu X. et al. Nanoparticle-loaded gels for topical delivery of nitrofurazone: Effect of particle size on skin permeation and retention // Journal of Drug Delivery Science and Technology. 2018. Vol. 45. pp. 367-372.
GOST all authors (up to 50)
Copy
Liu X., Shen B., Shen C., Zhong R., Wang X., Yuan H. Nanoparticle-loaded gels for topical delivery of nitrofurazone: Effect of particle size on skin permeation and retention // Journal of Drug Delivery Science and Technology. 2018. Vol. 45. pp. 367-372.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.jddst.2018.04.005
UR - https://doi.org/10.1016/j.jddst.2018.04.005
TI - Nanoparticle-loaded gels for topical delivery of nitrofurazone: Effect of particle size on skin permeation and retention
T2 - Journal of Drug Delivery Science and Technology
AU - Liu, Xiao
AU - Shen, Baode
AU - Shen, Chengying
AU - Zhong, Ruina
AU - Wang, Xiaohan
AU - Yuan, Hai-Long
PY - 2018
DA - 2018/06/01
PB - Elsevier
SP - 367-372
VL - 45
SN - 1773-2247
SN - 2588-8943
SN - 1157-1489
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Liu,
author = {Xiao Liu and Baode Shen and Chengying Shen and Ruina Zhong and Xiaohan Wang and Hai-Long Yuan},
title = {Nanoparticle-loaded gels for topical delivery of nitrofurazone: Effect of particle size on skin permeation and retention},
journal = {Journal of Drug Delivery Science and Technology},
year = {2018},
volume = {45},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/j.jddst.2018.04.005},
pages = {367--372},
doi = {10.1016/j.jddst.2018.04.005}
}