Journal of Drug Delivery Science and Technology, volume 57, pages 101609

Effects of spacers within a series of novel folate-containing lipoconjugates on the targeted delivery of nucleic acids

Shmendel Elena ¹

Kabilova Tatyana ²

Morozova Nina ¹

Зенкова М. А. ²

Maslov Mikhail ¹

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Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Vernadskogo Avenue 86, Moscow 119571, Russia. |

Institute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentieva Avenue 8, Novosibirsk, 630090, Russia |

Publication type: Journal Article

Publication date: 2020-06-01

Elsevier

Journal: Journal of Drug Delivery Science and Technology

Quartile SCImago

Quartile WOS

Impact factor: 5

ISSN: 17732247, 25888943

DOI: 10.1016/j.jddst.2020.101609

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Pharmaceutical Science

Abstract

Limitations regarding the targeted delivery of therapeutic nucleic acids into cancer cells can be overcome by developing a non-viral delivery system equipped with folate-containing conjugates. Here, we report the synthesis of novel folate-containing lipoconjugates (FLs), which differ by spacers between the hydrophobic domain and ligand (folic acid). FLs were incorporated into a liposome composed of the polycationic amphiphile 1,26-bis(cholest-5-en-3β-yloxycarbonylamino)-7,11,16,20-tetraazahexacosan tetrahydrochloride (2X3) and helper lipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE). At low (2/1) nitrogen to phosphate (N/P) ratio, liposomes containing 0.5 mol% FL with a short hydrophobic spacer and 2 mol% FL with medium hydrophilic spacer were compared with control liposomes containing 2 mol% FL with a polyethylene glycol spacer and showed higher transfection efficiency than non-targeted liposomal formulations and the commercial agent Lipofectamine 2000. At an N/P ratio of 4/1, the transfection efficiency of FL-containing liposomes were correlated neither with FL content within the liposomes nor FL structure.

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Citations by journals

	1 2 3 4 5
Pharmaceutics	Pharmaceutics, 5, 50% Pharmaceutics 5 publications, 50%
Russian Journal of Bioorganic Chemistry	Russian Journal of Bioorganic Chemistry, 2, 20% Russian Journal of Bioorganic Chemistry 2 publications, 20%
Biomaterials Science	Biomaterials Science, 1, 10% Biomaterials Science 1 publication, 10%
WSEAS Transactions on Applied and Theoretical Mechanics	WSEAS Transactions on Applied and Theoretical Mechanics, 1, 10% WSEAS Transactions on Applied and Theoretical Mechanics 1 publication, 10%
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Citations by publishers

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Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 5, 50% Multidisciplinary Digital Publishing Institute (MDPI) 5 publications, 50%
Pleiades Publishing	Pleiades Publishing, 2, 20% Pleiades Publishing 2 publications, 20%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 10% Royal Society of Chemistry (RSC) 1 publication, 10%
World Scientific and Engineering Academy and Society (WSEAS)	World Scientific and Engineering Academy and Society (WSEAS), 1, 10% World Scientific and Engineering Academy and Society (WSEAS) 1 publication, 10%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 1, 10% Cold Spring Harbor Laboratory 1 publication, 10%
	1 2 3 4 5

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Shmendel E. et al. Effects of spacers within a series of novel folate-containing lipoconjugates on the targeted delivery of nucleic acids // Journal of Drug Delivery Science and Technology. 2020. Vol. 57. p. 101609.

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Shmendel E., Kabilova T., Morozova N., Зенкова М. А., Maslov M. Effects of spacers within a series of novel folate-containing lipoconjugates on the targeted delivery of nucleic acids // Journal of Drug Delivery Science and Technology. 2020. Vol. 57. p. 101609.

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RIS Copy

TY - JOUR

DO - 10.1016/j.jddst.2020.101609

UR - https://doi.org/10.1016%2Fj.jddst.2020.101609

TI - Effects of spacers within a series of novel folate-containing lipoconjugates on the targeted delivery of nucleic acids

T2 - Journal of Drug Delivery Science and Technology

AU - Shmendel, Elena

AU - Kabilova, Tatyana

AU - Morozova, Nina

AU - Зенкова, М. А.

AU - Maslov, Mikhail

PY - 2020

DA - 2020/06/01 00:00:00

PB - Elsevier

SP - 101609

VL - 57

SN - 1773-2247

SN - 2588-8943

ER -

BibTex

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@article{2020_Shmendel,

author = {Elena Shmendel and Tatyana Kabilova and Nina Morozova and М. А. Зенкова and Mikhail Maslov},

title = {Effects of spacers within a series of novel folate-containing lipoconjugates on the targeted delivery of nucleic acids},

journal = {Journal of Drug Delivery Science and Technology},

year = {2020},

volume = {57},

publisher = {Elsevier},

month = {jun},

url = {https://doi.org/10.1016%2Fj.jddst.2020.101609},

pages = {101609},

doi = {10.1016/j.jddst.2020.101609}

}

Found error?

Publisher

Elsevier

Journal

Journal of Drug Delivery Science and Technology

Quartile SCImago

Quartile WOS

Impact factor

ISSN

17732247 (Print)
25888943 (Electronic)

Labs

Laboratory of Lipids

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