Interactions of the human telomeric DNA with terbium–amino acid complexes
Тип публикации: Journal Article
Дата публикации: 2006-10-01
scimago Q2
wos Q2
БС1
SJR: 0.621
CiteScore: 7.0
Impact factor: 3.2
ISSN: 01620134, 18733344
PubMed ID:
16842855
Biochemistry
Inorganic Chemistry
Краткое описание
The human telomeric DNA can form four-stranded structures: the G-rich strand adopts a G-quadruplex conformation stabilized by G-quartets and the C-rich strand may fold into an I-motif based on intercalated C.C(+) base pairs. There is intense interests in the design and synthesis of compounds which can target telomeric DNA and inhibit the telomerase activity. Here we report the thermodynamic studies of the two newly synthesized terbium-amino acid complexes bound to the human telomeric G-quadruplex and I-motif DNA which were studied by means of UV-Visible, DNA meltings, fluorescence and circular dichroism. These two complexes can bind to the human telomeric DNA and have shown different features on DNA stability, binding stoichiometry, and sequence-dependent fluorescence enhancement. To our knowledge, this is the first report to show terbium-amino acid complexes can interact with the human telomeric DNA.
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Xu H., Zhang H., Qu X. Interactions of the human telomeric DNA with terbium–amino acid complexes // Journal of Inorganic Biochemistry. 2006. Vol. 100. No. 10. pp. 1646-1652.
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Xu H., Zhang H., Qu X. Interactions of the human telomeric DNA with terbium–amino acid complexes // Journal of Inorganic Biochemistry. 2006. Vol. 100. No. 10. pp. 1646-1652.
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TY - JOUR
DO - 10.1016/j.jinorgbio.2006.05.015
UR - https://doi.org/10.1016/j.jinorgbio.2006.05.015
TI - Interactions of the human telomeric DNA with terbium–amino acid complexes
T2 - Journal of Inorganic Biochemistry
AU - Xu, Haixia
AU - Zhang, Haiyuan
AU - Qu, Xiaogang
PY - 2006
DA - 2006/10/01
PB - Elsevier
SP - 1646-1652
IS - 10
VL - 100
PMID - 16842855
SN - 0162-0134
SN - 1873-3344
ER -
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@article{2006_Xu,
author = {Haixia Xu and Haiyuan Zhang and Xiaogang Qu},
title = {Interactions of the human telomeric DNA with terbium–amino acid complexes},
journal = {Journal of Inorganic Biochemistry},
year = {2006},
volume = {100},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.jinorgbio.2006.05.015},
number = {10},
pages = {1646--1652},
doi = {10.1016/j.jinorgbio.2006.05.015}
}
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Xu, Haixia, et al. “Interactions of the human telomeric DNA with terbium–amino acid complexes.” Journal of Inorganic Biochemistry, vol. 100, no. 10, Oct. 2006, pp. 1646-1652. https://doi.org/10.1016/j.jinorgbio.2006.05.015.