Silatrane-sulfonamide hybrids: Synthesis, characterization, and evaluation of biological activity

• Synthesis of silatrane-sulfonamide hybrids is presented. • Characterization by NMR, FTIR, mass spectrometry and X-ray analysis • These compounds show antimicrobial activity A series of novel sulfonamide-bridged silatranes 3,4,6,7 has been synthesized by the reaction of N,N -dichloroarylsulfonamides 1a-d with 1-vinylsilatrane 2 and 1-allylsilatrane 5 . The structure of the silatrane-sulfonamide hybrids is characterized by elemental analysis, FT-IR, NMR ( 1 H, 13 C, 29 Si and 15 N) spectroscopy, high-resolution mass spectrometry, and X-ray diffraction analysis. The resulting hybrids 4a-d and 7a-d have been investigated by computational screening via ADMET and PASS. These compounds exhibit drug-like features, bioavailability and may have high enzyme-inhibitory activity. The screening ( in vitro ) of hybrids 4a,b,d and 7a,b for antimicrobial activities against pathogenic bacterial strains shows that these compounds possess antibacterial properties.