Journal of Pharmaceutical and Biomedical Analysis, volume 177, pages 112883
Microextraction of aromatic microbial metabolites by packed hypercrosslinked polystyrene from blood serum
Publication type: Journal Article
Publication date: 2020-01-01
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 3.4
ISSN: 07317085, 1873264X
Drug Discovery
Spectroscopy
Pharmaceutical Science
Clinical Biochemistry
Analytical Chemistry
Abstract
The article is devoted to the application of modern sample preparation technique - microextraction by packed sorbent (MEPS) - in conjunction with non-conventional type of sorbent - hypercrosslinked polystyrene, that was investigated for the first time in this work. Their combination was used to extract phenylcarboxylic acid-type aromatic microbial metabolites from serum samples of a healthy volunteer with following derivatization and GC-MS detection. As barrel insert and needle for MEPS with hypercrosslinked polystyrene is not produced, we designed a device to imitate the commercial MEPS system with packed granular biporous hypercrosslinked polystyrene. Nine aromatic microbial metabolites, including sepsis associated phenyllactic, 4-hydroxyphenyllactic and 4-hydroxyphenylacetic acids, were extracted from serum samples (recoveries were 20-70%) and a linear dependence was revealed in the most clinically significant range of concentrations (0.5-18 μM). The results obtained demonstrate the perspective of the applying of hypercrosslinked polystyrene in commercial devices for MEPS for the future analyses of biological samples, in particular for the early diagnosis of sepsis and treatment effectiveness control.
Top-30
Citations by journals
|
1
2
3
4
|
|
|
Molecules
4 publications, 36.36%
|
|
|
Talanta
1 publication, 9.09%
|
|
|
Microporous and Mesoporous Materials
1 publication, 9.09%
|
|
|
Biomedical Chromatography
1 publication, 9.09%
|
|
|
Macromolecular Materials and Engineering
1 publication, 9.09%
|
|
|
Journal of Separation Science
1 publication, 9.09%
|
|
|
Bioanalysis
1 publication, 9.09%
|
|
|
Russian Chemical Reviews
1 publication, 9.09%
|
|
|
1
2
3
4
|
Citations by publishers
|
1
2
3
4
|
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 36.36%
|
|
|
Wiley
3 publications, 27.27%
|
|
|
Elsevier
2 publications, 18.18%
|
|
|
Future Medicine
1 publication, 9.09%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 9.09%
|
|
|
1
2
3
4
|
- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2020,2021,2022,2023,2024],"ids":[0,0,0,0,0],"codes":[0,0,0,0,0],"imageUrls":["","","","",""],"datasets":[{"label":"Citations number","data":[3,3,1,3,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["27.27","27.27","9.09","27.27","9.09"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Molecules","Talanta","Microporous and Mesoporous Materials","Biomedical Chromatography","Macromolecular Materials and Engineering","Journal of Separation Science","Bioanalysis","Russian Chemical Reviews"],"ids":[1770,4331,6712,1016,9352,17445,15951,23802],"codes":[0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/AN2jnDN59NmKaS4CWLHAGstADL2DbnatQScsFA6C_medium.webp","\/storage\/images\/resized\/9Mus3KG1Tkd7Bwaurt8H3RwWh0CxRlGoO6ng9UK1_medium.webp"],"datasets":[{"label":"","data":[4,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[36.36,9.09,9.09,9.09,9.09,9.09,9.09,9.09],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Multidisciplinary Digital Publishing Institute (MDPI)","Wiley","Elsevier","Future Medicine","Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii"],"ids":[202,11,17,6949,9422],"codes":[0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/AN2jnDN59NmKaS4CWLHAGstADL2DbnatQScsFA6C_medium.webp","\/storage\/images\/resized\/9Mus3KG1Tkd7Bwaurt8H3RwWh0CxRlGoO6ng9UK1_medium.webp"],"datasets":[{"label":"","data":[4,3,2,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[36.36,27.27,18.18,9.09,9.09],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartiles":{"type":"bar","data":{"show":true,"labels":[2020,2021,2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0,0,0,0],"percentage":["0","0","0","0","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[1,0,0,0,0],"percentage":["9.09","0","0","0","0"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[0,1,0,1,0],"percentage":["0","9.09","0","9.09","0"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[2,2,1,2,1],"percentage":["18.18","18.18","9.09","18.18","9.09"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[0,0,0,0,0],"percentage":["0","0","0","0","0"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by SCImago per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartilesWs":{"type":"bar","data":{"show":true,"labels":[2020,2021,2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0,0,0,0],"percentage":["0","0","0","0","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[1,0,0,1,0],"percentage":["9.09","0","0","9.09","0"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[2,2,1,1,0],"percentage":["18.18","18.18","9.09","9.09","0"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[0,1,0,1,1],"percentage":["0","9.09","0","9.09","9.09"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[0,0,0,0,0],"percentage":["0","0","0","0","0"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by WoS per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Pautova A. K., Sobolev P. D., Revelsky A. I. Microextraction of aromatic microbial metabolites by packed hypercrosslinked polystyrene from blood serum // Journal of Pharmaceutical and Biomedical Analysis. 2020. Vol. 177. p. 112883.
GOST all authors (up to 50)
Copy
Pautova A. K., Sobolev P. D., Revelsky A. I. Microextraction of aromatic microbial metabolites by packed hypercrosslinked polystyrene from blood serum // Journal of Pharmaceutical and Biomedical Analysis. 2020. Vol. 177. p. 112883.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.jpba.2019.112883
UR - https://doi.org/10.1016/j.jpba.2019.112883
TI - Microextraction of aromatic microbial metabolites by packed hypercrosslinked polystyrene from blood serum
T2 - Journal of Pharmaceutical and Biomedical Analysis
AU - Pautova, Alisa K.
AU - Sobolev, Pavel D
AU - Revelsky, Alexander I
PY - 2020
DA - 2020/01/01 00:00:00
PB - Elsevier
SP - 112883
VL - 177
SN - 0731-7085
SN - 1873-264X
ER -
Cite this
BibTex
Copy
@article{2020_Pautova,
author = {Alisa K. Pautova and Pavel D Sobolev and Alexander I Revelsky},
title = {Microextraction of aromatic microbial metabolites by packed hypercrosslinked polystyrene from blood serum},
journal = {Journal of Pharmaceutical and Biomedical Analysis},
year = {2020},
volume = {177},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.jpba.2019.112883},
pages = {112883},
doi = {10.1016/j.jpba.2019.112883}
}