Journal of Pharmaceutical and Biomedical Analysis, volume 188, pages 113311
ESR INVESTIGATIONS of X-RAY EXPOSED DRUGS
Elif Tugce Sarcan
1
,
Asuman Tas
1
,
Mine Silindir Gunay
1
,
Asuman Yekta Ozer
1
,
Şeyda Çolak
2
,
Baki Hekimoglu
3
3
Health Sciences University, Diskapi Yildirim Beyazit Education and Research Hospital, Department of Radiology, 06110, Ankara, Turkey
|
Publication type: Journal Article
Publication date: 2020-09-01
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 3.4
ISSN: 07317085, 1873264X
Drug Discovery
Spectroscopy
Pharmaceutical Science
Clinical Biochemistry
Analytical Chemistry
Abstract
X-ray is used in several areas for analysis, imaging, sterilisation and security. X-ray machines are increasingly used in the entrance of the airports, shopping centres, etc. for security purposes. Therefore, human beings and belongings are frequently exposed to X-ray by transiting these checkpoints at various sites such as airports, shopping centres etc. This study aims is to investigate the X-rays potential effects (arising from security machines) on different groups of medicines which are analgesics (acetaminophen, acetylsalicylic acid, naproxen, flurbiprofen), anti-diabetics (metformin HCl, pioglitazone), PPI’s (lansoprazole, pantoprazole sesquihydrate), anti-hypertensives (losartan, clopidogrel hydrogen sulphate), heart failure medicines (verapamil HCl, spironolactone) used frequently and daily, by using ESR analysis. Coated acetylsalicylic acid tablets showed different intensities of ESR signals after 58 mGy irradiation. It thought to be the result of the coating polymer (Hydroxypropylmethylcellulose (HPMC)). According to the ESR results which were obtained for 0,24-58 mGy irradiated drugs- 1 hour after irradiation (refrigerated during this period) X-ray did not affect those medicines except the acetylsalicylic acid tablets significantly. The meaningful differences were only obtained between the non-irradiated, and 58 mGy irradiated acetylsalicylic acid tablets. Therefore, it can be concluded that X-ray exposed medicines, except coated acetylsalicylic acid tablets (after 58 mGy irradiation), can be used safely for the irradiation levels used in this study (0.24 mGy-0.58 mGy). In addition those data, ESR analyses were followed by other analysis such as FT-IR, DSC/TGA, dissolution, SEM, etc., and they are planned to be published soon.
Top-30
Citations by journals
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1
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Radiation Physics and Chemistry
1 publication, 20%
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Journal of Pharmaceutical Sciences
1 publication, 20%
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Journal of Applied Polymer Science
1 publication, 20%
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Polymer Degradation and Stability
1 publication, 20%
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Russian Chemical Reviews
1 publication, 20%
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1
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Citations by publishers
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Elsevier
3 publications, 60%
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Wiley
1 publication, 20%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 20%
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Sarcan E. T. et al. ESR INVESTIGATIONS of X-RAY EXPOSED DRUGS // Journal of Pharmaceutical and Biomedical Analysis. 2020. Vol. 188. p. 113311.
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Sarcan E. T., Tas A., Silindir Gunay M., Ozer A. Y., Çolak Ş., Hekimoglu B. ESR INVESTIGATIONS of X-RAY EXPOSED DRUGS // Journal of Pharmaceutical and Biomedical Analysis. 2020. Vol. 188. p. 113311.
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TY - JOUR
DO - 10.1016/j.jpba.2020.113311
UR - https://doi.org/10.1016/j.jpba.2020.113311
TI - ESR INVESTIGATIONS of X-RAY EXPOSED DRUGS
T2 - Journal of Pharmaceutical and Biomedical Analysis
AU - Sarcan, Elif Tugce
AU - Tas, Asuman
AU - Silindir Gunay, Mine
AU - Ozer, Asuman Yekta
AU - Çolak, Şeyda
AU - Hekimoglu, Baki
PY - 2020
DA - 2020/09/01 00:00:00
PB - Elsevier
SP - 113311
VL - 188
SN - 0731-7085
SN - 1873-264X
ER -
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@article{2020_Sarcan,
author = {Elif Tugce Sarcan and Asuman Tas and Mine Silindir Gunay and Asuman Yekta Ozer and Şeyda Çolak and Baki Hekimoglu},
title = {ESR INVESTIGATIONS of X-RAY EXPOSED DRUGS},
journal = {Journal of Pharmaceutical and Biomedical Analysis},
year = {2020},
volume = {188},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/j.jpba.2020.113311},
pages = {113311},
doi = {10.1016/j.jpba.2020.113311}
}