Journal of Photochemistry and Photobiology A: Chemistry, volume 401, pages 112783
Meso-substituted-BODIPY based fluorescent biomarker: Spectral characteristics, photostability and possibilities for practical application
Galina B Guseva
1
,
Elena V Antina
1
,
Airat R. Kayumov
2
,
Svetlana A Lisovskaya
3
,
Olga A. Lodochnikova
2, 4
,
Daut R. Islamov
2, 4
,
К. Усачев
2
,
Sergei Boichuk
3
,
Liliya E. Nikitina
3, 5
Publication type: Journal Article
Publication date: 2020-10-01
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 4.3
ISSN: 10106030, 18732666
General Chemistry
General Chemical Engineering
General Physics and Astronomy
Abstract
A fluorescent biomarker based on the boron(III) complex with meso-4-methoxycarbonylbutyl-substituted 3,3',5,5'-tetramethyl-2,2′-dipyrromethene (BODIPY) was synthesized. The BODIPY exhibits a large extinction coefficient (lgɛ ∼4.82–5.00) at 496–501 nm and high fluorescence quantum yield (∼77–100%) in the blue-green region of the spectrum (509–518 nm). The maximal fluorescence quantum yield (φ) is observed in non-polar media (∼100%) while φ slightly decreases to ∼90% in alcohols (with the exception of octanol-1) and to ∼77% in electron-donating dimethyl sulfoxide (DMSO). The BODIPY fluorophore demonstrates high photostability with the half-life of 41.4 and 91 hours in toluene and cyclohexane, respectively. The proposed luminophore preferentially stains gram-positive bacteria and can be used for differential staining of gram-positive and gram-negative bacteria in mixed cultures. BODIPY also accumulates in the cytoplasm of the mammalian cells giving polar micro-speckled staining pattern which is more intensive in the tumor cells when compared to the fibroblasts. The pronounced affinity of BODIPY to mitochondria of eukaryotic cells could be used for specific staining of these organelles.
Top-30
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Journal of Photochemistry and Photobiology A: Chemistry
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1 publication, 5.26%
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1 publication, 5.26%
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Inorganics
1 publication, 5.26%
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1 publication, 5.26%
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Citations by publishers
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Elsevier
9 publications, 47.37%
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3 publications, 15.79%
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American Chemical Society (ACS)
2 publications, 10.53%
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2 publications, 10.53%
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Springer Nature
1 publication, 5.26%
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American Society for Microbiology
1 publication, 5.26%
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Pleiades Publishing
1 publication, 5.26%
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- We do not take into account publications without a DOI.
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- Statistics recalculated weekly.
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Guseva G. B. et al. Meso-substituted-BODIPY based fluorescent biomarker: Spectral characteristics, photostability and possibilities for practical application // Journal of Photochemistry and Photobiology A: Chemistry. 2020. Vol. 401. p. 112783.
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Guseva G. B., Antina E. V., Berezin M. Y., Pavelyev R. S., Kayumov A. R., Sharafutdinov I., Lisovskaya S. A., Lodochnikova O. A., R. Islamov D., Усачев К., Boichuk S., Nikitina L. E. Meso-substituted-BODIPY based fluorescent biomarker: Spectral characteristics, photostability and possibilities for practical application // Journal of Photochemistry and Photobiology A: Chemistry. 2020. Vol. 401. p. 112783.
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TY - JOUR
DO - 10.1016/j.jphotochem.2020.112783
UR - https://doi.org/10.1016/j.jphotochem.2020.112783
TI - Meso-substituted-BODIPY based fluorescent biomarker: Spectral characteristics, photostability and possibilities for practical application
T2 - Journal of Photochemistry and Photobiology A: Chemistry
AU - Guseva, Galina B
AU - Antina, Elena V
AU - Berezin, Mikhail Y.
AU - Pavelyev, Roman S.
AU - Kayumov, Airat R.
AU - Sharafutdinov, Irshad
AU - Lisovskaya, Svetlana A
AU - Lodochnikova, Olga A.
AU - R. Islamov, Daut
AU - Усачев, К.
AU - Boichuk, Sergei
AU - Nikitina, Liliya E.
PY - 2020
DA - 2020/10/01 00:00:00
PB - Elsevier
SP - 112783
VL - 401
SN - 1010-6030
SN - 1873-2666
ER -
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@article{2020_Guseva,
author = {Galina B Guseva and Elena V Antina and Mikhail Y. Berezin and Roman S. Pavelyev and Airat R. Kayumov and Irshad Sharafutdinov and Svetlana A Lisovskaya and Olga A. Lodochnikova and Daut R. Islamov and К. Усачев and Sergei Boichuk and Liliya E. Nikitina},
title = {Meso-substituted-BODIPY based fluorescent biomarker: Spectral characteristics, photostability and possibilities for practical application},
journal = {Journal of Photochemistry and Photobiology A: Chemistry},
year = {2020},
volume = {401},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.jphotochem.2020.112783},
pages = {112783},
doi = {10.1016/j.jphotochem.2020.112783}
}