Mayo Clinic Proceedings

, volume 92 , issue 4 , pages 544-554

Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia

Peter J. Grahn ¹

Igor Lavrov ¹

Dimitry G. Sayenko ²

Meegan G. Van Straaten ³

Megan L. Gill ³

Jeffrey A. Strommen ³

Jonathan S. Calvert ⁴

Dina I Drubach ¹

Lisa Beck ³

Margaux B. Linde ³

Andrew R Thoreson ³

Cesar Díaz López ³

Aldo A Mendez ¹

Parag Gad ²

Yury P. Gerasimenko ^{5, 6}

V. Reggie Edgerton ²

Kristin D Zhao ³

Kendall H. Lee ³

Hide authors affiliations Show authors affiliations: 6 affiliations

Department of Neurologic Surgery, Mayo Clinic, Rochester, MN. |

[Department of Integrative Biology and Physiology, University of California, Los Angeles] |

Rehabilitation Medicine Research Center, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN |

⁴

Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN |

⁵

Department of Integrative Biology and Physiology, University of California Los Angeles |

⁶

Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia |

Publication type: Journal Article

Publication date: 2017-04-03

Elsevier

Mayo Clinic Proceedings

scimago Q1

wos Q1

SJR: 2.001

CiteScore: 14.1

Impact factor: 6.7

ISSN: 00256196, 19425546

DOI: 10.1016/j.mayocp.2017.02.014

Copy DOI

PubMed ID: 28385196

General Medicine

Abstract

We report a case of chronic traumatic paraplegia in which epidural electrical stimulation (EES) of the lumbosacral spinal cord enabled (1) volitional control of task-specific muscle activity, (2) volitional control of rhythmic muscle activity to produce steplike movements while side-lying, (3) independent standing, and (4) while in a vertical position with body weight partially supported, voluntary control of steplike movements and rhythmic muscle activity. This is the first time that the application of EES enabled all of these tasks in the same patient within the first 2 weeks (8 stimulation sessions total) of EES therapy.

Found

2 citations

Inanici Fatma

37 publications, 874 citations, 7 reviews

h-index: 13

University of Washington

Research interests

Pain

Spinal Cord Injury

1 citation

Nurullin Leniz

PhD in Biological/biomedical sciences

64 publications, 521 citations, 1 review

h-index: 13

Kazan Institute of Biochemistry and Biophysics of the Kazan Scientific Center of the Russian Academy of Sciences

Kazan State Medical University

1 citation

Rybak Ilya

144 publications, 6 910 citations

h-index: 47

Drexel University

1 citation

Prilutsky Boris

105 publications, 2 715 citations

h-index: 29

Georgia Institute of technology

1 citation

Salazar Betsy

27 publications, 140 citations

h-index: 7

Houston Methodist Hospital

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Cite this

GOST |

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GOST Copy

Grahn P. J. et al. Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia // Mayo Clinic Proceedings. 2017. Vol. 92. No. 4. pp. 544-554.

GOST all authors (up to 50) Copy

Grahn P. J., Lavrov I., Sayenko D. G., Van Straaten M. G., Gill M. L., Strommen J. A., Calvert J. S., Drubach D. I., Beck L., Linde M. B., Thoreson A. R., López C. D., Mendez A. A., Gad P., Gerasimenko Y. P., Edgerton V. R., Zhao K. D., Lee K. H. Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia // Mayo Clinic Proceedings. 2017. Vol. 92. No. 4. pp. 544-554.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.mayocp.2017.02.014

UR - https://doi.org/10.1016/j.mayocp.2017.02.014

TI - Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia

T2 - Mayo Clinic Proceedings

AU - Grahn, Peter J.

AU - Lavrov, Igor

AU - Sayenko, Dimitry G.

AU - Van Straaten, Meegan G.

AU - Gill, Megan L.

AU - Strommen, Jeffrey A.

AU - Calvert, Jonathan S.

AU - Drubach, Dina I

AU - Beck, Lisa

AU - Linde, Margaux B.

AU - Thoreson, Andrew R

AU - López, Cesar Díaz

AU - Mendez, Aldo A

AU - Gad, Parag

AU - Gerasimenko, Yury P.

AU - Edgerton, V. Reggie

AU - Zhao, Kristin D

AU - Lee, Kendall H.

PY - 2017

DA - 2017/04/03

PB - Elsevier

SP - 544-554

IS - 4

VL - 92

PMID - 28385196

SN - 0025-6196

SN - 1942-5546

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2017_Grahn,

author = {Peter J. Grahn and Igor Lavrov and Dimitry G. Sayenko and Meegan G. Van Straaten and Megan L. Gill and Jeffrey A. Strommen and Jonathan S. Calvert and Dina I Drubach and Lisa Beck and Margaux B. Linde and Andrew R Thoreson and Cesar Díaz López and Aldo A Mendez and Parag Gad and Yury P. Gerasimenko and V. Reggie Edgerton and Kristin D Zhao and Kendall H. Lee},

title = {Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia},

journal = {Mayo Clinic Proceedings},

year = {2017},

volume = {92},

publisher = {Elsevier},

month = {apr},

url = {https://doi.org/10.1016/j.mayocp.2017.02.014},

number = {4},

pages = {544--554},

doi = {10.1016/j.mayocp.2017.02.014}

}

MLA

Cite this

MLA Copy

Grahn, Peter J., et al. “Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia.” Mayo Clinic Proceedings, vol. 92, no. 4, Apr. 2017, pp. 544-554. https://doi.org/10.1016/j.mayocp.2017.02.014.

Publisher

Elsevier

Journal

Mayo Clinic Proceedings

scimago Q1

wos Q1

SJR

2.001

CiteScore

14.1

Impact factor

6.7

ISSN

00256196 (Print)

19425546 (Electronic)

Profiles

Dimitry G Sayenko