Novel thyroid hormone analogues, enzyme inhibitors and mimetics, and their action
Publication type: Journal Article
Publication date: 2017-12-01
scimago Q1
wos Q2
SJR: 1.198
CiteScore: 8.1
Impact factor: 3.6
ISSN: 03037207, 18728057
PubMed ID:
28408161
Biochemistry
Molecular Biology
Endocrinology
Abstract
Thyroid hormones (THs) play key roles in modulating the overall metabolism of the body, protein synthesis, fat metabolism, neuronal and bone growth, and cardiovascular as well as renal functions. In this review, we discuss on the thyroid hormone synthesis and activation, thyroid hormone receptors (TRs) and mechanism of action, applications of thyroid hormone analogues, particularly the compounds that are selective ligands for TRβ receptors, or enzyme inhibitors for the treatment of thyroidal disorders with a specific focus on thyroid peroxidase and iodothyronine deiodinases. We also discuss on the development of small-molecule deiodinase mimetics and their mechanism of deiodination, as these compounds have the potential to regulate the thyroid hormone levels.
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Total citations:
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Citations from 2024:
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GOST
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Mondal S., Mugesh G. Novel thyroid hormone analogues, enzyme inhibitors and mimetics, and their action // Molecular and Cellular Endocrinology. 2017. Vol. 458. pp. 91-104.
GOST all authors (up to 50)
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Mondal S., Mugesh G. Novel thyroid hormone analogues, enzyme inhibitors and mimetics, and their action // Molecular and Cellular Endocrinology. 2017. Vol. 458. pp. 91-104.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.mce.2017.04.006
UR - https://doi.org/10.1016/j.mce.2017.04.006
TI - Novel thyroid hormone analogues, enzyme inhibitors and mimetics, and their action
T2 - Molecular and Cellular Endocrinology
AU - Mondal, Santanu
AU - Mugesh, Govindasamy
PY - 2017
DA - 2017/12/01
PB - Elsevier
SP - 91-104
VL - 458
PMID - 28408161
SN - 0303-7207
SN - 1872-8057
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2017_Mondal,
author = {Santanu Mondal and Govindasamy Mugesh},
title = {Novel thyroid hormone analogues, enzyme inhibitors and mimetics, and their action},
journal = {Molecular and Cellular Endocrinology},
year = {2017},
volume = {458},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.mce.2017.04.006},
pages = {91--104},
doi = {10.1016/j.mce.2017.04.006}
}