Nebulized Lidocaine in COVID-19, An Hypothesis
Ziad A Ali
1
,
Rif S. El-Mallakh
1
Publication type: Journal Article
Publication date: 2020-11-01
scimago Q3
wos Q4
SJR: 0.387
CiteScore: 4.0
Impact factor: 0.8
ISSN: 03069877, 15322777
PubMed ID:
32505070
General Medicine
Abstract
Coronavirus Diseases-2019 (COVID-19) has caused a large global outbreak and has been declared as a pandemic by the World Health Organization (WHO). It has been proposed that COVID-19-related hyperinflammation and dysregulated immune response might play a critical role in developing a cytokine storm which usually progresses to a life-threatening acute lung injury or acute respiratory distress syndrome in infected individuals. Lidocaine, a local analgesic and anti-arrhythmic, is known for its anti-inflammatory actions and has been used to reduce cough and improve respiratory symptoms in severe asthmatic patients. It has a demonstrated safety profile. It is proposed that nebulized lidocaine might be beneficial in reducing cytokines, protecting patients’ lungs and improving outcomes in COVID-19 patients when administered via inhalation as an adjunctive treatment for severe respiratory symptoms in patients fighting the novel Coronavirus. Additional investigation is warranted.
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Total citations:
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Citations from 2025:
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GOST
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Ali Z. A., El-Mallakh R. S. Nebulized Lidocaine in COVID-19, An Hypothesis // Medical Hypotheses. 2020. Vol. 144. p. 109947.
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Ali Z. A., El-Mallakh R. S. Nebulized Lidocaine in COVID-19, An Hypothesis // Medical Hypotheses. 2020. Vol. 144. p. 109947.
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RIS
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TY - JOUR
DO - 10.1016/j.mehy.2020.109947
UR - https://doi.org/10.1016/j.mehy.2020.109947
TI - Nebulized Lidocaine in COVID-19, An Hypothesis
T2 - Medical Hypotheses
AU - Ali, Ziad A
AU - El-Mallakh, Rif S.
PY - 2020
DA - 2020/11/01
PB - Elsevier
SP - 109947
VL - 144
PMID - 32505070
SN - 0306-9877
SN - 1532-2777
ER -
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@article{2020_Ali,
author = {Ziad A Ali and Rif S. El-Mallakh},
title = {Nebulized Lidocaine in COVID-19, An Hypothesis},
journal = {Medical Hypotheses},
year = {2020},
volume = {144},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.mehy.2020.109947},
pages = {109947},
doi = {10.1016/j.mehy.2020.109947}
}