Phosphates of bridgehead alcohols as putative inositol monophosphatase inhibitors: molecular design and synthetic approach
Тип публикации: Journal Article
Дата публикации: 2011-09-01
scimago Q3
wos Q3
БС1
SJR: 0.305
CiteScore: 3
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Краткое описание
To enhance the lipophilicity of d -3,5,6-trideoxyinositol monophosphate, the IMPase inhibitor, its bridgehead analogues were suggested on the basis of molecular modeling. Adamantane-1,2- and 1,4-diols were converted into their 1-phosphates via the step of benzylic protection of the secondary hydroxy groups; the Baeyer–Villiger oxidation of 1-hydroxyadamantan-2-one occurred to initially cleave C(1)–C(2) bond.
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Zefirova O. N. et al. Phosphates of bridgehead alcohols as putative inositol monophosphatase inhibitors: molecular design and synthetic approach // Mendeleev Communications. 2011. Vol. 21. No. 5. pp. 242-244.
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Zefirova O. N., Raguzin I. S., Gogol V. V., Nurieva E. V., Belenikin M. S. Phosphates of bridgehead alcohols as putative inositol monophosphatase inhibitors: molecular design and synthetic approach // Mendeleev Communications. 2011. Vol. 21. No. 5. pp. 242-244.
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TY - JOUR
DO - 10.1016/j.mencom.2011.09.003
UR - https://doi.org/10.1016/j.mencom.2011.09.003
TI - Phosphates of bridgehead alcohols as putative inositol monophosphatase inhibitors: molecular design and synthetic approach
T2 - Mendeleev Communications
AU - Zefirova, Olga N
AU - Raguzin, Ivan S
AU - Gogol, Vladimir V
AU - Nurieva, Evgeniya V
AU - Belenikin, Maxim S
PY - 2011
DA - 2011/09/01
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 242-244
IS - 5
VL - 21
SN - 0959-9436
SN - 1364-551X
ER -
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@article{2011_Zefirova,
author = {Olga N Zefirova and Ivan S Raguzin and Vladimir V Gogol and Evgeniya V Nurieva and Maxim S Belenikin},
title = {Phosphates of bridgehead alcohols as putative inositol monophosphatase inhibitors: molecular design and synthetic approach},
journal = {Mendeleev Communications},
year = {2011},
volume = {21},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {sep},
url = {https://doi.org/10.1016/j.mencom.2011.09.003},
number = {5},
pages = {242--244},
doi = {10.1016/j.mencom.2011.09.003}
}
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Zefirova, Olga N., et al. “Phosphates of bridgehead alcohols as putative inositol monophosphatase inhibitors: molecular design and synthetic approach.” Mendeleev Communications, vol. 21, no. 5, Sep. 2011, pp. 242-244. https://doi.org/10.1016/j.mencom.2011.09.003.