Mendeleev Communications

, том 27 , издание 6 , страницы 559-561

‘On-solvent’ new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1 H )-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4 H -chromene scaffold

Тип публикации: Journal Article

Дата публикации: 2017-11-24

OOO Zhurnal "Mendeleevskie Soobshcheniya"

Mendeleev Communications

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SJR: 0.305

CiteScore: 3

Impact factor: 1.7

ISSN: 09599436, 1364551X

DOI: 10.1016/j.mencom.2017.11.006

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General Chemistry

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Sodium acetate catalyzed assembling of salicylaldehydes, malononitrile and 4-hydroxy-6-methylpyridin-2(1H)-one in small amount of ethanol gives rapidly (5 min) substituted 4-pyridinyl-2-amino-4H-chromenes in 82–99% yields. This novel domino reaction opens the fast, facile, and flexible way to the new type of functionalized 2-amino-4H-chromene scaffold containing uracil-like moiety, which are relevant compounds for diverse biomedical applications.

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Elinson M. N. et al. ‘On-solvent’ new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1 H )-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4 H -chromene scaffold // Mendeleev Communications. 2017. Vol. 27. No. 6. pp. 559-561.

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Elinson M. N., Ryzhkov F. V., Vereshchagin A. N., Korshunov A. D., Novikov R. G., Egorov M. P. ‘On-solvent’ new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1 H )-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4 H -chromene scaffold // Mendeleev Communications. 2017. Vol. 27. No. 6. pp. 559-561.

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TY - JOUR

DO - 10.1016/j.mencom.2017.11.006

UR - https://linkinghub.elsevier.com/retrieve/pii/S0959943617302432

TI - ‘On-solvent’ new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1 H )-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4 H -chromene scaffold

T2 - Mendeleev Communications

AU - Elinson, M. N.

AU - Ryzhkov, Fedor V.

AU - Vereshchagin, Anatoly N.

AU - Korshunov, Alexander D

AU - Novikov, Roman G.

AU - Egorov, Mikhail P.

PY - 2017

DA - 2017/11/24

PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"

SP - 559-561

IS - 6

VL - 27

SN - 0959-9436

SN - 1364-551X

ER -

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@article{2017_Elinson,

author = {M. N. Elinson and Fedor V. Ryzhkov and Anatoly N. Vereshchagin and Alexander D Korshunov and Roman G. Novikov and Mikhail P. Egorov},

title = {‘On-solvent’ new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1 H )-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4 H -chromene scaffold},

journal = {Mendeleev Communications},

year = {2017},

volume = {27},

publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},

month = {nov},

url = {https://linkinghub.elsevier.com/retrieve/pii/S0959943617302432},

number = {6},

pages = {559--561},

doi = {10.1016/j.mencom.2017.11.006}

}

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Elinson, M. N., et al. “‘On-solvent’ new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1 H )-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4 H -chromene scaffold.” Mendeleev Communications, vol. 27, no. 6, Nov. 2017, pp. 559-561. https://linkinghub.elsevier.com/retrieve/pii/S0959943617302432.