, volume 27 , issue 6 , pages 623-625

Structural requirements for molecular design of positive allosteric modulators of AMPA receptor

Eugene V. Radchenko ^{1, 2}

Dmitry S Karlov ^{1, 2}

Mstislav I. Lavrov ^{1, 2}

V. A. Palyulin ^{1, 2}

Hide authors affiliations Show authors affiliations: 2 affiliations

Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation |

Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation |

Publication type: Journal Article

Publication date: 2017-11-24

OOO Zhurnal "Mendeleevskie Soobshcheniya"

Mendeleev Communications

scimago Q3

wos Q3

SJR: 0.305

CiteScore: 3.0

Impact factor: 1.7

ISSN: 09599436, 1364551X

DOI: 10.1016/j.mencom.2017.11.029

Copy DOI

General Chemistry

Abstract

Positive allosteric modulators of AMPA receptor are prospective for the development of safe and efficacious agents for the correction of disruption of the central nervous system functions. Joint application of molecular docking, MFTA and CoMFA QSAR modelling, and pharmacophore analysis affords a consistent picture of structural requirements for molecular design of novel promising bivalent modulators with high activity, including overall twisted-staple shape of a molecule, hydrophobic central core, and polar hydrogen bond acceptor groups in peripheral parts of a molecule.

Found

3 citations

Vasilenko Dmitry

🥼 🤝

PhD in Chemistry

34 publications, 293 citations

h-index: 10

Lomonosov Moscow State University

Research interests

Medicinal Chemistry

Organic Chemistry

1 citation

Ustyugov Aleksey

🥼

DSc in Biological/biomedical sciences

83 publications, 1 031 citations, 21 reviews

h-index: 16

Institute of Physiologically Active Compounds of the Russian Academy of Science

Federal Research Center of Problem of Chemical Physics and Medicinal Chemistry RAS

Research interests

Medicinal Chemistry

Neurodegeneration

1 citation

Sadovnikov Kirill

PhD in Chemistry

17 publications, 98 citations

h-index: 7

A.V. Topchiev Institute of Petrochemical Synthesis RAS

Top-30

Journals

	1 2 3 4 5 6 7 8 9
Mendeleev Communications	Mendeleev Communications, 9, 52.94% Mendeleev Communications 9 publications, 52.94%
Molecules	Molecules, 2, 11.76% Molecules 2 publications, 11.76%
Biomolecules	Biomolecules, 1, 5.88% Biomolecules 1 publication, 5.88%
Molecular Neurobiology	Molecular Neurobiology, 1, 5.88% Molecular Neurobiology 1 publication, 5.88%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 5.88% Russian Chemical Reviews 1 publication, 5.88%
MedChemComm	MedChemComm, 1, 5.88% MedChemComm 1 publication, 5.88%
Biomeditsinskaya Khimiya	Biomeditsinskaya Khimiya, 1, 5.88% Biomeditsinskaya Khimiya 1 publication, 5.88%
Russian Chemical Bulletin	Russian Chemical Bulletin, 1, 5.88% Russian Chemical Bulletin 1 publication, 5.88%
	1 2 3 4 5 6 7 8 9

Publishers

	1 2 3 4 5 6 7 8 9
OOO Zhurnal "Mendeleevskie Soobshcheniya"	OOO Zhurnal "Mendeleevskie Soobshcheniya", 9, 52.94% OOO Zhurnal "Mendeleevskie Soobshcheniya" 9 publications, 52.94%
MDPI	MDPI, 3, 17.65% MDPI 3 publications, 17.65%
Springer Nature	Springer Nature, 2, 11.76% Springer Nature 2 publications, 11.76%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 5.88% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 5.88%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 5.88% Royal Society of Chemistry (RSC) 1 publication, 5.88%
Institute of Biochemistry	Institute of Biochemistry, 1, 5.88% Institute of Biochemistry 1 publication, 5.88%
	1 2 3 4 5 6 7 8 9

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST |

Cite this

GOST Copy

Radchenko E. V. et al. Structural requirements for molecular design of positive allosteric modulators of AMPA receptor // Mendeleev Communications. 2017. Vol. 27. No. 6. pp. 623-625.

GOST all authors (up to 50) Copy

Radchenko E. V., Karlov D. S., Lavrov M. I., Palyulin V. A. Structural requirements for molecular design of positive allosteric modulators of AMPA receptor // Mendeleev Communications. 2017. Vol. 27. No. 6. pp. 623-625.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.mencom.2017.11.029

UR - https://doi.org/10.1016/j.mencom.2017.11.029

TI - Structural requirements for molecular design of positive allosteric modulators of AMPA receptor

T2 - Mendeleev Communications

AU - Radchenko, Eugene V.

AU - Karlov, Dmitry S

AU - Lavrov, Mstislav I.

AU - Palyulin, V. A.

PY - 2017

DA - 2017/11/24

PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"

SP - 623-625

IS - 6

VL - 27

SN - 0959-9436

SN - 1364-551X

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2017_Radchenko,

author = {Eugene V. Radchenko and Dmitry S Karlov and Mstislav I. Lavrov and V. A. Palyulin},

title = {Structural requirements for molecular design of positive allosteric modulators of AMPA receptor},

journal = {Mendeleev Communications},

year = {2017},

volume = {27},

publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},

month = {nov},

url = {https://doi.org/10.1016/j.mencom.2017.11.029},

number = {6},

pages = {623--625},

doi = {10.1016/j.mencom.2017.11.029}

}

MLA

Cite this

MLA Copy

Radchenko, Eugene V., et al. “Structural requirements for molecular design of positive allosteric modulators of AMPA receptor.” Mendeleev Communications, vol. 27, no. 6, Nov. 2017, pp. 623-625. https://doi.org/10.1016/j.mencom.2017.11.029.

Publisher

OOO Zhurnal "Mendeleevskie Soobshcheniya"

Journal

Mendeleev Communications

scimago Q3

wos Q3

SJR

0.305

CiteScore

3.0

Impact factor

1.7

ISSN

09599436 (Print)

1364551X (Electronic)