The first AMPA receptor negative modulators based on the tetrahydroquinazoline scaffold
Kseniya N Sedenkova
1, 2
,
E. B. Averina
1, 2
,
Anna A Nazarova
3
,
Yuri Grishin
3
,
Dmitry S Karlov
1, 2
,
Vladimir L Zamoyski
4
,
Vladimir V. Grigoriev
1, 2
,
Tamara S. Kuznetsova
3
,
V. A. Palyulin
1, 2
1
3
Publication type: Journal Article
Publication date: 2018-07-01
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
A convenient approach to novel symmetric bispyrimidine diamines comprises SNAr reactions of 4-fluoropyrimidine N-oxide with alkane-α,ω-diamines with subsequent reduction of N-oxide function. The obtained substances were tested in patch-clamp experiments for the influence on the kainateinduced currents in Purkinje neurons and showed negative modulating effect.
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Sedenkova K. N. et al. The first AMPA receptor negative modulators based on the tetrahydroquinazoline scaffold // Mendeleev Communications. 2018. Vol. 28. No. 4. pp. 423-425.
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Sedenkova K. N., Averina E. B., Nazarova A. A., Grishin Y., Karlov D. S., Zamoyski V. L., Grigoriev V. V., Kuznetsova T. S., Palyulin V. A. The first AMPA receptor negative modulators based on the tetrahydroquinazoline scaffold // Mendeleev Communications. 2018. Vol. 28. No. 4. pp. 423-425.
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RIS
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TY - JOUR
DO - 10.1016/j.mencom.2018.07.028
UR - https://doi.org/10.1016/j.mencom.2018.07.028
TI - The first AMPA receptor negative modulators based on the tetrahydroquinazoline scaffold
T2 - Mendeleev Communications
AU - Sedenkova, Kseniya N
AU - Averina, E. B.
AU - Nazarova, Anna A
AU - Grishin, Yuri
AU - Karlov, Dmitry S
AU - Zamoyski, Vladimir L
AU - Grigoriev, Vladimir V.
AU - Kuznetsova, Tamara S.
AU - Palyulin, V. A.
PY - 2018
DA - 2018/07/01
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 423-425
IS - 4
VL - 28
SN - 0959-9436
SN - 1364-551X
ER -
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BibTex (up to 50 authors)
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@article{2018_Sedenkova,
author = {Kseniya N Sedenkova and E. B. Averina and Anna A Nazarova and Yuri Grishin and Dmitry S Karlov and Vladimir L Zamoyski and Vladimir V. Grigoriev and Tamara S. Kuznetsova and V. A. Palyulin},
title = {The first AMPA receptor negative modulators based on the tetrahydroquinazoline scaffold},
journal = {Mendeleev Communications},
year = {2018},
volume = {28},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {jul},
url = {https://doi.org/10.1016/j.mencom.2018.07.028},
number = {4},
pages = {423--425},
doi = {10.1016/j.mencom.2018.07.028}
}
Cite this
MLA
Copy
Sedenkova, Kseniya N., et al. “The first AMPA receptor negative modulators based on the tetrahydroquinazoline scaffold.” Mendeleev Communications, vol. 28, no. 4, Jul. 2018, pp. 423-425. https://doi.org/10.1016/j.mencom.2018.07.028.