Simple antitumor model compounds for cross-conjugated cyclopentenone prostaglandins
Nikolay S Vostrikov
1
,
Leonid V. Spirikhin
1
,
Alexander N Lobov
1
,
Airat M Gimazetdinov
1
,
Zulfiya R. Zileeva
2
,
Zainutdin R Macaev
1
,
Kasimir K. Pivnitsky
3
,
Mansur S Miftakhov
1
2
Publication type: Journal Article
Publication date: 2019-07-01
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
Unstable methyl (5-methylidene-4-oxocyclopent-2-en-1-yl)acetate, having a ring moiety of J-type prostaglandins (PGJs) and similar cytotoxicity, reacts with EtSH and other thiols with formation of mono-and bis-adducts, which have been further converted by oxidation with mCPBA into corresponding stable mono-sulfones possessing cytotoxic effect most probably due to in vivo regeneration of the starting dienone. Thus, the derived sulfones can be used as transport forms for original dienone as a pharmacologically important moiety of Δ12-PGJ2 and similar prostaglandins.
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Vostrikov N. S. et al. Simple antitumor model compounds for cross-conjugated cyclopentenone prostaglandins // Mendeleev Communications. 2019. Vol. 29. No. 4. pp. 372-374.
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Vostrikov N. S., Spirikhin L. V., Lobov A. N., Gimazetdinov A. M., Zileeva Z. R., Vakhitova Y. V., Macaev Z. R., Pivnitsky K. K., Miftakhov M. S. Simple antitumor model compounds for cross-conjugated cyclopentenone prostaglandins // Mendeleev Communications. 2019. Vol. 29. No. 4. pp. 372-374.
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TY - JOUR
DO - 10.1016/j.mencom.2019.07.003
UR - https://doi.org/10.1016/j.mencom.2019.07.003
TI - Simple antitumor model compounds for cross-conjugated cyclopentenone prostaglandins
T2 - Mendeleev Communications
AU - Vostrikov, Nikolay S
AU - Spirikhin, Leonid V.
AU - Lobov, Alexander N
AU - Gimazetdinov, Airat M
AU - Zileeva, Zulfiya R.
AU - Vakhitova, Yulia V.
AU - Macaev, Zainutdin R
AU - Pivnitsky, Kasimir K.
AU - Miftakhov, Mansur S
PY - 2019
DA - 2019/07/01
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 372-374
IS - 4
VL - 29
SN - 0959-9436
SN - 1364-551X
ER -
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BibTex (up to 50 authors)
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@article{2019_Vostrikov,
author = {Nikolay S Vostrikov and Leonid V. Spirikhin and Alexander N Lobov and Airat M Gimazetdinov and Zulfiya R. Zileeva and Yulia V. Vakhitova and Zainutdin R Macaev and Kasimir K. Pivnitsky and Mansur S Miftakhov},
title = {Simple antitumor model compounds for cross-conjugated cyclopentenone prostaglandins},
journal = {Mendeleev Communications},
year = {2019},
volume = {29},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {jul},
url = {https://doi.org/10.1016/j.mencom.2019.07.003},
number = {4},
pages = {372--374},
doi = {10.1016/j.mencom.2019.07.003}
}
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MLA
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Vostrikov, Nikolay S., et al. “Simple antitumor model compounds for cross-conjugated cyclopentenone prostaglandins.” Mendeleev Communications, vol. 29, no. 4, Jul. 2019, pp. 372-374. https://doi.org/10.1016/j.mencom.2019.07.003.