Synthetic modulator of chymotrypsin activity based on p-tert-butylthiacalix[4]arene
Olga A. Mostovaya
1
,
Yuliya A Valiullina
2
,
Chang T Chan
1
,
Olga S Potrekeeva
1
,
Pavel Padnya
1
,
Yuriy F. Zuev
2
,
Publication type: Journal Article
Publication date: 2019-09-01
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
A p-tert-butylthiacalix[4]arene derivative containing tryptophan moieties on the lower rim was synthesized and proposed as a chymotrypsin inhibitor. Its ability to competitively inhibit the enzyme was revealed by kinetic methods. A mechanism of the inhibitory action has been established, which consists in the binding of macrocycle tryptophan moieties to the enzyme active site, resulting in its blocking.
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Total citations:
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Citations from 2025:
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(25%)
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GOST
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Valiullina Y. A. et al. Synthetic modulator of chymotrypsin activity based on p-tert-butylthiacalix[4]arene // Mendeleev Communications. 2019. Vol. 29. No. 5. pp. 520-522.
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Mostovaya O. A., Valiullina Y. A., Chan C. T., Potrekeeva O. S., Padnya P., Zuev Y. F., Stoikov I. Synthetic modulator of chymotrypsin activity based on p-tert-butylthiacalix[4]arene // Mendeleev Communications. 2019. Vol. 29. No. 5. pp. 520-522.
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RIS
Copy
TY - JOUR
DO - 10.1016/j.mencom.2019.09.014
UR - https://doi.org/10.1016/j.mencom.2019.09.014
TI - Synthetic modulator of chymotrypsin activity based on p-tert-butylthiacalix[4]arene
T2 - Mendeleev Communications
AU - Mostovaya, Olga A.
AU - Valiullina, Yuliya A
AU - Chan, Chang T
AU - Potrekeeva, Olga S
AU - Padnya, Pavel
AU - Zuev, Yuriy F.
AU - Stoikov, Ivan
PY - 2019
DA - 2019/09/01
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 520-522
IS - 5
VL - 29
SN - 0959-9436
SN - 1364-551X
ER -
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BibTex (up to 50 authors)
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@article{2019_Valiullina,
author = {Olga A. Mostovaya and Yuliya A Valiullina and Chang T Chan and Olga S Potrekeeva and Pavel Padnya and Yuriy F. Zuev and Ivan Stoikov},
title = {Synthetic modulator of chymotrypsin activity based on p-tert-butylthiacalix[4]arene},
journal = {Mendeleev Communications},
year = {2019},
volume = {29},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {sep},
url = {https://doi.org/10.1016/j.mencom.2019.09.014},
number = {5},
pages = {520--522},
doi = {10.1016/j.mencom.2019.09.014}
}
Cite this
MLA
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Valiullina, Yuliya A., et al. “Synthetic modulator of chymotrypsin activity based on p-tert-butylthiacalix[4]arene.” Mendeleev Communications, vol. 29, no. 5, Sep. 2019, pp. 520-522. https://doi.org/10.1016/j.mencom.2019.09.014.
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