Synthesis of an allosteric modulator of ionotropic glutamate receptors
Mstislav I. Lavrov
1, 2
,
Oleg V. Stroganov
3
,
Vladimir L Zamoyski
4
,
Vladimir V. Grigoriev
1, 2
,
Maxim E Zapolskiy
5
,
Sergey V Sysolyatin
6
,
Valeriy V Malykhin
6
,
Vladimir N Surmachev
6
,
V. A. Palyulin
1, 2
1
5
QM PHARMA LLC, Skolkovo Innovation Center, 143026 Moscow, Russian Federation
|
Publication type: Journal Article
Publication date: 2020-03-01
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
Synthesis of 6-[4-methoxy-3-(pyrrolidin-1-ylmethyl)benzyl]-1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione has been carried out and optimized. In vitro studies using electrophysiological patch clamp technique have revealed a negative effect of this compound on kainateinduced currents in Purkinje neurons in a wide range of concentrations from 10−11 to 10−6 m.
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Lavrov M. I. et al. Synthesis of an allosteric modulator of ionotropic glutamate receptors // Mendeleev Communications. 2020. Vol. 30. No. 2. pp. 156-158.
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Lavrov M. I., Stroganov O. V., Zamoyski V. L., Grigoriev V. V., Zapolskiy M. E., Sysolyatin S. V., Malykhin V. V., Surmachev V. N., Palyulin V. A. Synthesis of an allosteric modulator of ionotropic glutamate receptors // Mendeleev Communications. 2020. Vol. 30. No. 2. pp. 156-158.
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RIS
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TY - JOUR
DO - 10.1016/j.mencom.2020.03.008
UR - https://doi.org/10.1016/j.mencom.2020.03.008
TI - Synthesis of an allosteric modulator of ionotropic glutamate receptors
T2 - Mendeleev Communications
AU - Lavrov, Mstislav I.
AU - Stroganov, Oleg V.
AU - Zamoyski, Vladimir L
AU - Grigoriev, Vladimir V.
AU - Zapolskiy, Maxim E
AU - Sysolyatin, Sergey V
AU - Malykhin, Valeriy V
AU - Surmachev, Vladimir N
AU - Palyulin, V. A.
PY - 2020
DA - 2020/03/01
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 156-158
IS - 2
VL - 30
SN - 0959-9436
SN - 1364-551X
ER -
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BibTex (up to 50 authors)
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@article{2020_Lavrov,
author = {Mstislav I. Lavrov and Oleg V. Stroganov and Vladimir L Zamoyski and Vladimir V. Grigoriev and Maxim E Zapolskiy and Sergey V Sysolyatin and Valeriy V Malykhin and Vladimir N Surmachev and V. A. Palyulin},
title = {Synthesis of an allosteric modulator of ionotropic glutamate receptors},
journal = {Mendeleev Communications},
year = {2020},
volume = {30},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {mar},
url = {https://doi.org/10.1016/j.mencom.2020.03.008},
number = {2},
pages = {156--158},
doi = {10.1016/j.mencom.2020.03.008}
}
Cite this
MLA
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Lavrov, Mstislav I., et al. “Synthesis of an allosteric modulator of ionotropic glutamate receptors.” Mendeleev Communications, vol. 30, no. 2, Mar. 2020, pp. 156-158. https://doi.org/10.1016/j.mencom.2020.03.008.