Mendeleev Communications, volume 30, issue 5, pages 636-638
Synthesis and biological activity of polyfluorinated p-aminosalicylic acids and their amides
Publication type: Journal Article
Publication date: 2020-09-01
Journal:
Mendeleev Communications
Quartile SCImago
Q3
Quartile WOS
Q3
Impact factor: 1.9
ISSN: 09599436, 1364551X
General Chemistry
Abstract
Polyfluorinated analogues of salicylamide and p-aminosalicylic acid have been synthesized based on methyl polyfluorosalicylates. Polyfluorosalicylamides were obtained by the reaction with aqueous ammonia, while 4-aminopolyfluorosalicylic acids were prepared in two steps via regio-oriented nucleophilic replacement of para-positioned fluorine atom with azido group followed by its reduction. 3,4,5-Trifluorosalicylamide showed pronounced analgesic in vivo activity in hot plate test while 4-amino-3,5-difluorosalicylic acid revealed high tuberculostatic activity.
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Burgart Y. V. et al. Synthesis and biological activity of polyfluorinated p-aminosalicylic acids and their amides // Mendeleev Communications. 2020. Vol. 30. No. 5. pp. 636-638.
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Burgart Y. V., Shchur I. V., Shchegol’kov E., Saloutin V. Synthesis and biological activity of polyfluorinated p-aminosalicylic acids and their amides // Mendeleev Communications. 2020. Vol. 30. No. 5. pp. 636-638.
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TY - JOUR
DO - 10.1016/j.mencom.2020.09.028
UR - https://doi.org/10.1016/j.mencom.2020.09.028
TI - Synthesis and biological activity of polyfluorinated p-aminosalicylic acids and their amides
T2 - Mendeleev Communications
AU - Burgart, Yanina V.
AU - Shchur, Irina V
AU - Shchegol’kov, E.V.
AU - Saloutin, Victor
PY - 2020
DA - 2020/09/01 00:00:00
PB - Elsevier
SP - 636-638
IS - 5
VL - 30
SN - 0959-9436
SN - 1364-551X
ER -
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@article{2020_Burgart,
author = {Yanina V. Burgart and Irina V Shchur and E.V. Shchegol’kov and Victor Saloutin},
title = {Synthesis and biological activity of polyfluorinated p-aminosalicylic acids and their amides},
journal = {Mendeleev Communications},
year = {2020},
volume = {30},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/j.mencom.2020.09.028},
number = {5},
pages = {636--638},
doi = {10.1016/j.mencom.2020.09.028}
}
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Burgart, Yanina V., et al. “Synthesis and biological activity of polyfluorinated p-aminosalicylic acids and their amides.” Mendeleev Communications, vol. 30, no. 5, Sep. 2020, pp. 636-638. https://doi.org/10.1016/j.mencom.2020.09.028.