Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings
Linh Nguyen
1
,
Hieu H Truong
2
,
Victor N. Khrustalev
2, 3
,
Sang T Truong
1
,
Dat Nguyen
1
,
Son T Mai
1
,
Van Man Tran
1
,
Anh Tuan Le
1
1
Publication type: Journal Article
Publication date: 2020-11-01
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
Six novel phane-structured diazacrowns containing γ-piperidone and pyridine rings were synthesized from podand 2-+,6-bis(2-formylphenoxymethyl)pyridine, with the γ-piperidone moiety having been constructed in the course of its domino condensation with simple ketones and ammonium acetate. The compounds were tested in vitro for antimicrobial and cytotoxic activity against four human cancer cell lines (Hep-G2, RD, MCF-7, Lu-1) and the Vero cell line. X-Ray structure study of one representative compound revealed its rac-1RS,23SR,24RS,26SR configuration.
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GOST
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Nguyen L. et al. Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings // Mendeleev Communications. 2020. Vol. 30. No. 6. pp. 753-755.
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Nguyen L., Truong H. H., Khrustalev V. N., Truong S. T., Nguyen D., Mai S. T., Tran V. M., Le A. T. Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings // Mendeleev Communications. 2020. Vol. 30. No. 6. pp. 753-755.
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RIS
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TY - JOUR
DO - 10.1016/j.mencom.2020.11.021
UR - https://doi.org/10.1016/j.mencom.2020.11.021
TI - Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings
T2 - Mendeleev Communications
AU - Nguyen, Linh
AU - Truong, Hieu H
AU - Khrustalev, Victor N.
AU - Truong, Sang T
AU - Nguyen, Dat
AU - Mai, Son T
AU - Tran, Van Man
AU - Le, Anh Tuan
PY - 2020
DA - 2020/11/01
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 753-755
IS - 6
VL - 30
SN - 0959-9436
SN - 1364-551X
ER -
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@article{2020_Nguyen,
author = {Linh Nguyen and Hieu H Truong and Victor N. Khrustalev and Sang T Truong and Dat Nguyen and Son T Mai and Van Man Tran and Anh Tuan Le},
title = {Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings},
journal = {Mendeleev Communications},
year = {2020},
volume = {30},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {nov},
url = {https://doi.org/10.1016/j.mencom.2020.11.021},
number = {6},
pages = {753--755},
doi = {10.1016/j.mencom.2020.11.021}
}
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MLA
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Nguyen, Linh, et al. “Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings.” Mendeleev Communications, vol. 30, no. 6, Nov. 2020, pp. 753-755. https://doi.org/10.1016/j.mencom.2020.11.021.