Novel bivalent positive allosteric AMPA receptor modulator of bis-amide series
Nadezhda S Temnyakova
1
,
Mstislav I. Lavrov
2, 3
,
Dmitry S Karlov
1
,
Yuri Grishin
1
,
Vladimir L Zamoyski
4
,
Vladimir V. Grigoriev
2, 3
,
E. B. Averina
2, 3
,
V. A. Palyulin
2, 3
1
2
Publication type: Journal Article
Publication date: 2021-03-31
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
A series of bis-amides of bis(aminoalkyl)benzenes and diaminoalkanes were synthesized. Positive modulation of kainate-induced transmembrane currents was registered on Purkinje neurons for isobutyric acid derivative with 1,4-bis(aminomethyl)benzene linker (40% potentiation at 1 nm). This compound also demonstrated a neuroprotective effect at 0.1 nm in an oxidative stress model in HT-22 cells when applied 24 h before H2O2.
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9
Total citations:
9
Citations from 2025:
1
(11.11%)
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GOST
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Temnyakova N. S. et al. Novel bivalent positive allosteric AMPA receptor modulator of bis-amide series // Mendeleev Communications. 2021. Vol. 31. No. 2. pp. 216-218.
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Temnyakova N. S., Vasilenko D. V., Lavrov M. I., Karlov D. S., Grishin Y., Zamoyski V. L., Grigoriev V. V., Averina E. B., Palyulin V. A. Novel bivalent positive allosteric AMPA receptor modulator of bis-amide series // Mendeleev Communications. 2021. Vol. 31. No. 2. pp. 216-218.
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RIS
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TY - JOUR
DO - 10.1016/j.mencom.2021.03.023
UR - https://doi.org/10.1016/j.mencom.2021.03.023
TI - Novel bivalent positive allosteric AMPA receptor modulator of bis-amide series
T2 - Mendeleev Communications
AU - Temnyakova, Nadezhda S
AU - Vasilenko, Dmitry V.
AU - Lavrov, Mstislav I.
AU - Karlov, Dmitry S
AU - Grishin, Yuri
AU - Zamoyski, Vladimir L
AU - Grigoriev, Vladimir V.
AU - Averina, E. B.
AU - Palyulin, V. A.
PY - 2021
DA - 2021/03/31
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 216-218
IS - 2
VL - 31
SN - 0959-9436
SN - 1364-551X
ER -
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BibTex (up to 50 authors)
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@article{2021_Temnyakova,
author = {Nadezhda S Temnyakova and Dmitry V. Vasilenko and Mstislav I. Lavrov and Dmitry S Karlov and Yuri Grishin and Vladimir L Zamoyski and Vladimir V. Grigoriev and E. B. Averina and V. A. Palyulin},
title = {Novel bivalent positive allosteric AMPA receptor modulator of bis-amide series},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {mar},
url = {https://doi.org/10.1016/j.mencom.2021.03.023},
number = {2},
pages = {216--218},
doi = {10.1016/j.mencom.2021.03.023}
}
Cite this
MLA
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Temnyakova, Nadezhda S., et al. “Novel bivalent positive allosteric AMPA receptor modulator of bis-amide series.” Mendeleev Communications, vol. 31, no. 2, Mar. 2021, pp. 216-218. https://doi.org/10.1016/j.mencom.2021.03.023.
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